Author: caroline

1 POST-DOC position - Open September 2018
by

A 3-year postdoctoral position is available in the group of Dr Stéphane NOSELLI at the ‘institut de Biologie Valrose’ (iBV), Université Côte d’Azur in Nice, FR.

Our lab investigates the origin of biological chirality and the role of the actin cytoskeleton and associated myosins (type I myosins) in this fundamental property. We approach this problem by studying how Left-Right asymmetry is established in Drosophila, using multidisciplinary approaches addressing a number of primary questions: How is symmetry breaking taking place? What are the molecular determinants of asymmetry/chirality? How molecular chirality translates into higher order organ asymmetry, bridging different
biological scales? How is the Myosin I system conserved during evolution?
This project aims at characterizing the role of the actin cytoskeleton in LR symmetry breaking and asymmetric morphogenesis, and its interaction with actin-associated factors that we have recently identified through genetic screening.

Highly motivated candidates with original thinking and background in Developmental Biology, Cell Biology, Biochemistry are encouraged to apply. Previous experience in actin/cytoskeleton biology would be a plus.
Interested candidates can contact S. Noselli (noselli@unice.fr).

The ‘institut de Biologie Valrose’ (27 teams; 300 persons; 25 nationalities) is an international institute (English is the working language) with a rich and vivid scientific environment. iBV provides state of the art core facilities, with a collaborative and lively atmosphere in a gorgeous city/region. (ibv.unice.fr/EN/index.php)

Selected publications:
Speder et al., Nature 2006
Gettings et al., PLoS Biol 2010
Suzanne et al., Cur Biol 2010
Petzoldt et al., Development 2012
Coutelis et al., Dev Cell 2013
Géminard et al., Genesis 2014
Coutelis et al., EMBO Reports 2014
Gonzales-Morales et al., Dev Cell 2015
Van de Bor et al., Cell Reports 2015
Rousset et al., PLoS Genetics 2017
Roumengous et al., Cell Reports 2017

CDD AI - 18 months - Starting October 2018
by

CDD Assistant Ingénieur, 18 mois

Laboratoire

iBV, Institut de Biologie Valrose, CNRS UMR7277, Inserm U1091, UNS

Equipe - Localisation du poste

BIPOA, Bio-Ingénierie et Physiopathologie Ostéo-Articulaire
(http://ibv.unice.fr/research-team/scimeca/)
Faculté de Médecine, 28 av de Valombrose

Poste à pourvoir

A partir de la mi-septembre 2018

Projet

Dans un partenariat académiques/industriels, le projet financé par la Banque Publique d’Investissement a pour objectif le développement d’une nouvelle génération de ciments phosphocalciques élastiques et résistants pour le traitement des fractures vertébrales.

Programme de travail et compétences requises

Le programme de travail repose sur l’étude des interactions entre les ciments phosphocalciques développés et les cellules osseuses (ostéoblastes, ostéoclastes), grâce à la mise en oeuvre des techniques suivantes :

• Préparation et mise en forme des ciments pour les tests in vitro ;
• Culture cellulaire et mesures de la viabilité/prolifération ;
• Transcriptomique (RT-qPCR) et protéomique (ELISA multiplex)
• Immunohistochimie

La personne sera aussi impliquée dans l’analyse d’implants en site osseux réalisés par nos collaborateurs responsables de l’expérimentation in vivo, grâce à une technique de microscopie quantitative (SHG, Second Harmonic Generation)
Sont attendus : rigueur et réactivité dans la conduite des expériences et dans la mise en forme des résultats ; aptitudes à interagir au sein d’un réseau impliquant 3 laboratoires académiques et 2 industriels

Contact

Jean-Claude SCIMECA
scimeca@unice.fr

1 PostDoc - 3 years - Start October 2018
by

POST-DOC POSITION AVAILABLE:
Regulation of neuronal RNA granules and function in long-term memory

A three-year post-doctoral position is available in the group of Florence Besse
(http://ibv.unice.fr/research-team/besse/) at the Institute of Biology Valrose (iBV-UMR7277, Nice, France).

Project description

Long-term molecular and structural changes occurring at synapses in response to neuronal activation provide the mechanistic bases for the establishment and retention of memories, and are altered in both developmental and age-related memory disorders. Such changes rely on local experience-induced translation of quiescent mRNAs packaged together with regulatory proteins into neuronal RNA granules transported and stored at synapses. How RNA granules are remodeled in response to neuronal activity to relieve translation repression of mRNAs is unclear. Furthermore, the importance of such a remodeling in the establishment of long-term memories remains to be demonstrated in vivo.
The successful candidate will address these questions in Drosophila, by dissecting the cellular and molecular mechanisms underlying the remodeling of conserved neuronal RNP granules in response to activity. She/he will also participate in characterizing how such a remodeling impacts on the establishment of long-term memory traces assessed via learning and memory behavior assays (in collaboration with K. Keleman’s lab).

Qualifications and Experience

Candidates should have a PhD in cell biology, molecular biology, genetics, or neurobiology.
Experience with fly genetics, behavior assays and/or transcriptomics will be considered advantageous.
English is the working language in the lab and in the Institute.

Funding

The position is funded for 3 years, and the starting date is October 2018

Applications

Interested candidates are encouraged to send a CV, a description of research interests and accomplishments, and names and contact information of 2 referees to Florence Besse: besse@unice.fr.

Selected references:

- De Graeve F. and Besse F. (2018). Biol.chem doi: 10.1515/hsz-2018-0141
- Medioni C., Ephrussi A. and Besse F. (2015). Nat. Protoc. doi: 10.1038/nprot.2015.034.
- Marchetti G. et al., (2014). J. Neurosci. doi: 10.1523/JNEUROSCI.3285-13.2014.
- Medioni C. et al., (2014). Cur Biol. doi: 10.1016/j.cub.2014.02.038.