PPAR Res. 2020 Aug 13;2020:3608315. doi: 10.1155/2020/3608315. eCollection 2020.
Siyue Du 1, Nicole Wagner # 1, Kay-Dietrich Wagner # 1
1 Université Côte d’Azur, CNRS, INSERM, iBV, 06107 Nice, France.
# Contributed equally.
PPARs are ligand-activated transcriptional factors that belong to the nuclear receptor superfamily. Among them, PPAR alpha and PPAR gamma are prone to exert an antiangiogenic effect, whereas PPAR beta/delta has an opposite effect in physiological and pathological conditions. Angiogenesis has been known as a hallmark of cancer, and our recent works also demonstrate that vascular-specific PPAR beta/delta overexpression promotes tumor angiogenesis and progression in vivo. In this review, we will mainly focus on the role of PPAR beta/delta in tumor angiogenesis linked to the tumor microenvironment to further facilitate tumor progression and metastasis. Moreover, the crosstalk between PPAR beta/delta and its downstream key signal molecules involved in tumor angiogenesis will also be discussed, and the network of interplay between them will further be established in the review.