From MBI, Singapore

will give a seminar entitled :

New perspectives on cell-cell adhesion

Abstract :

In this presentation I will cover different aspects of cell-cell junction mechanics that my lab has been working on in the last 5 years.

I will first present how we understand cell-cell adhesion in term of energy dissipation at junction rather than energy of adhesion. I will exemplify how cell regulate the viscosity of the cytoskeleton using E-cadherin dependent activation of EGFR. I will show how selectivity of cell-cell adhesion can be understood in term of matching the dynamics properties of the cytoskeleton between both adhesive cells rather than by selective adhesion of transmembrane binders.

I will then present our model to study how intercellular lumens can form anisotropically between two cells. In this context I will detail the role of microenvironment on the directional growth of canaliculi.

Lastly, I will present the high content imaging platform we develop to address the biomechanics of neighbor exchange and lumenogenesis in spatially controlled organoids (Gastruloids and liver). I will show how Neural networks can be trained on the large amount of data we can gather to quantify organoids morphologies from the sub cellular to whole organoid level.