1 Doctoral position - starting October 2020
1 Doctoral position - starting October 2020

Doctoral position at the Côte d’Azur & Sorbonne University

Studying the molecular control and the mechanics of sea urchin gastrulation: a model for epithelial folding

Epithelial folding is a key process in the life of all animals. During embryogenesis, this process takes place notably during gastrulation. In the laboratory, we use the sea urchin embryo to study the mechanisms, mechanics and molecular control of epithelial folding. Sea urchin gastrulae combine a number of outstanding features making this model system a unique opportunity to study folding: (i)  external development and tissue simplicity enabling both experimentation and modeling approaches; (ii) cell transparency allowing in toto light sheet imaging; (iii) known key signaling factors and available methods for functional analyses; and (iv) mechanically accessible tissues permitting direct measurements of tissue mechanical properties. Given these features, the sea urchin gastrula is thus a  perfect playground for both biologists and biophysicists. The aim is to provide new insights on the  fundamental process of epithelial folding both at the mechanical and molecular levels.

The proposed project is a collaborative work between two laboratories (Rauzi M. at iBV in Nice and  Croce J. at the LBDV at the marine station in Villefranche-sur-Mer) that gather people from different backgrounds (biology, informatics, physics, and engineering) to generate an interdisciplinary and synergistic group in an international environment.

Seeking a talented and very motivated candidate.
Deadline: April 27th, 2020. Starting date: October 2020.
Send as soon as possible a CV, a motivation letter, master scores/ranking and reference letters to: matteo.rauzi@univ-cotedazur.fr and jeni.croce@obs-vlfr.fr
CROCE EVOINSIDE / RAUZI LAB

1 Postdoctoral position - Starting before the end of 2020
1 Postdoctoral position - Starting before the end of 2020

Postdoctoral position at the University Côte d’Azur

Studying the mechanisms and mechanics of sea urchin gastrulation: a model for epithelial folding

During embryo gastrulation one of the key morphogenetic processes is tissue folding. We use the sea urchin embryo, a spherical monolayer epithelium that folds its vegetal plate forming a tube: the future gut. What are the mechanisms and the mechanical foces driving folding is still not well understood.The sea urchin gastrula combines a number of outstanding features making this model system a unique opportunity to study the mechanisms and mechanics of tissue folding: (1) simplicity; (2) transparencey for in toto light sheet imaging; (3) known key signaling factors; (4) the gastrula is a mechanically accessible tissue: it can be partitioned, cells can be transplanted, micro-indentation and micro-pipetting techniques can be applied to measure tissue mechanical properties. The sea urchin gastrula is thus a perfect playground for biologists and biophysicists.

The projects developed in the lab gather people from different backgrounds (biology, informatics, physics, and engineering) to generate an interdisciplinary and synergistic group in an international environment.

Seeking talanted candidates preferibly with expereince in micro pipetting, nano/μ indentation, live imaging, light sheet microscopy or marine model systems.

Deadline: May 10th, 2020. Starting date: Before the end of 2020.

Send a CV, motivation letter and reference letters to matteo.rauzi@univ-cotedazur.fr

RAUZI LAB: http://ibv.unice.fr/research-team/rauzi