Neuronal RNP granules: from physiological to pathological assemblies.
Biol Chem. 2018 Jun 27;399(7):623-635. doi: 10.1515/hsz-2018-0141.
De Graeve F1, Besse F1.
1. Université Côte d’Azur, CNRS, Inserm, Institut de Biologie Valrose, F-06100 Nice, France.
Neuronal cells rely on macro- and micro-cellular compartmentalization to rapidly process information, and respond locally to external stimuli. Such a cellular organization is achieved via the assembly of neuronal ribonucleoprotein (RNP) granules, dynamic membrane-less organelles enriched in RNAs and associated regulatory proteins. In this review, we discuss how these high-order structures transport mRNAs to dendrites and axons, and how they contribute to the spatio-temporal regulation of localized mRNA translation. We also highlight how recent biophysical studies have shed light on the mechanisms underlying neuronal RNP granule dynamic assembly, remodeling and maturation, in both physiological and pathological contexts.