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Frederic JAMME & Frank WIEN
September 27 at 11:00
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From: Soleil Synchrotron, DISCO Beamline
Will give a seminar entitled:
SOLEIL is the French synchrotron, both a large-scale facility and a research laboratory
Abstract
The SOLEIL synchrotron is both a service platform open to all scientific communities and a research laboratory. Synchrotron radiation enables measurements across a wide variety of length and time scales whilst exploiting its wide photon energy range, from hard X-ray to infrared, to provide chemical and morphological characterization with high selectivity. Life science research at synchrotron radiation sources has been remarkably productive since their inception over 40 years ago. In particular, X-ray crystallography beamlines have had a major impact for structural biology. Recent revolutions in both single-particle cryo-electron microscopy (cryo EM) and prediction of protein folds have changed the way we look at integrative approaches. The integration of cryo EM with synchrotron-based techniques will greatly facilitate the correlation of molecular and structural information from the atomic to cell levels. The combined expertise of the life science beamline teams at SOLEIL is the basis for the development of a post-upgrade approach to integrative biology. The Health and Well-Being Scientific Section at SOLEIL is an active group consisting of 30 experts in various fields.
Today, new synchrotron based bioimaging techniques, enlarge the scope of cell and tissue imaging with a huge potential for biological research and medical diagnosis. The ongoing upgrade of the SOLEIL synchrotron will contribute to the emergence of methods aimed to improve the imaging capabilities of cells, tissues, and organs at high spatial and temporal resolution. In this presentation, I will present a panel of studies that have been done using the different imaging beamlines dedicated to life science at SOLEIL with a focus on the UV fluorescence imaging developed at the DISCO beamline within the last past years.
Frédéric Jamme (Synchrotron SOLEIL, Saclay) is responsible of the synchrotron UV-Visible beamline DISCO dedicated to chemistry, biochemistry and cell biology. He is an expert in the application of different types of synchrotron radiation to study biological objects and materials, including multimodal approaches for label-free imaging of cell structures. Frederic Jamme is head of the Health&well-being scientific group. The combined expertise of the life sciences beamline teams at SOLEIL forms the Health&well-being scientific Group. Since the last 4 years, the group has been very active in adopting a multidisciplinary and integrated approach aware of recent evolutions/revolutions in the field of biology.