From MRC UCL

will give a seminar entitled :

Cell division: from archaea to eukaryotes

The Baum lab is interested in the generation of biological form. Since the shape and internal organisation of each cell is determined by a combination of physics, biochemistry and information processing, he use a wide range of techniques to address the problem, including molecular biology, genetics, high-content RNA interference (RNAi) screening, live cell imaging, microfabrication, biophysical techniques and computational modeling. The wider aims of his research are to better understand the evolution of eukaryotic cell shape, to determine how cells regulate their form, and to determine how these processes contribute to normal tissue development and homeostasis and, when they go awry, to the evolution of metastatic cancer.

Selected Publications:

Hunter GL, et al (2016). Coordinated control of Notch/Delta signalling and cell cycle progression drives lateral inhibition-mediated tissue patterning. Development (Cambridge, England), 143 (13), 2305-2310.

Dey G, et al (2016). On the Archaeal Origins of Eukaryotes and the Challenges of Inferring Phenotype from Genotype. Trends in Cell Biology, 26 (7), 476-485. doi:10.1016/j.tcb.2016.03.009

Rodrigues NTL, et al (2015). Kinetochore-localized PP1-Sds22 couples chromosome segregation to polar relaxation. Nature, 524 (7566), 489-+. doi:10.1038/nature14496

Baum D & Baum B (2014). An inside-out origin for the eukaryotic cell. BMC Biol, 12, 76. doi:10.1186/s12915-014-0076-2 Lancaster OM, et al (2013). Mitotic rounding alters cell geometry to ensure efficient bipolar spindle formation. Dev Cell, 25 (3), 270-283. doi:10.1016/j.devcel.2013.03.014

Marinari E, et al (2012). Live-cell delamination counterbalances epithelial growth to limit tissue overcrowding. Nature, 484 (7395), 542-545. doi:10.1038/nature10984

Matthews HK, et al (2012). Changes in ect2 localization couple actomyosin-dependent cell shape changes to mitotic progression. Developmental Cell, 23 (2), 371-383. doi:10.1016/j.devcel.2012.06.003