Mol Cell Endocrinol. 2021 Jan 20;111172. doi: 10.1016/j.mce.2021.111172. Online ahead of print.
Ioannis Oikonomakos 1, Lahiru Chamara Weerasinghe Arachchige 1, Andreas Schedl 2
1 Université Côte d’Azur, Inserm, CNRS, Institut de Biologie Valrose, 06108, Nice, France.
2 Université Côte d’Azur, Inserm, CNRS, Institut de Biologie Valrose, 06108, Nice, France. Electronic address: email@example.com.
The adrenal cortex is the main steroid producing organ of the human body. Studies on adrenal tissue renewal have been neglected for many years, but recent intensified research has seen tremendous progress in our understanding of tissue formation and renewal. However, cell turnover of the adrenal cortex appears to be complex and several cell populations have been identified that can differentiate into steroidogenic cells and contribute to adrenal cortex renewal. The purpose of this review is to provide an overview of how the adrenal cortex develops and how stem cell populations relate to its developmental progenitors. Finally, we will summarize present and future approaches to harvest the potential of progenitor/stem cells for future cell replacement therapies.