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June 9 at 11:00
From: Institut de Génomique Fonctionnelle de Lyon (IGFL)
Will give a seminar entitled:
Deciphering protein interaction networks in live cells: new approaches, new perspectives
Biological pathways rely on the formation of intricate protein interaction networks called interactomes. Getting a comprehensive map of interactomes implies developing tools that allow capturing transient and low affinity protein-protein interactions (PPIs) in live conditions.
During my talk I will present several experimental strategies that have been developed in our lab for the large-scale capture of interactomes and analysis of PPI dynamics in human cells. These experimental strategies rely on innovative tools derived from BiFC (Bimolecular Fluorescence Complementation), TurboID and SplitFAST systems. Together, these tools provide an unprecedented resolution of the dynamics and complexity of specific interactomes in any live cell context of interest.