January 24 at 11:30
From MRC UCL
will give a seminar entitled :
Cell division: from archaea to eukaryotes
The Baum lab is interested in the generation of biological form. Since the shape and internal organisation of each cell is determined by a combination of physics, biochemistry and information processing, he use a wide range of techniques to address the problem, including molecular biology, genetics, high-content RNA interference (RNAi) screening, live cell imaging, microfabrication, biophysical techniques and computational modeling. The wider aims of his research are to better understand the evolution of eukaryotic cell shape, to determine how cells regulate their form, and to determine how these processes contribute to normal tissue development and homeostasis and, when they go awry, to the evolution of metastatic cancer.
Hunter GL, et al (2016). Coordinated control of Notch/Delta signalling and cell cycle progression drives lateral inhibition-mediated tissue patterning. Development (Cambridge, England), 143 (13), 2305-2310.
Dey G, et al (2016). On the Archaeal Origins of Eukaryotes and the Challenges of Inferring Phenotype from Genotype. Trends in Cell Biology, 26 (7), 476-485. doi:10.1016/j.tcb.2016.03.009
Rodrigues NTL, et al (2015). Kinetochore-localized PP1-Sds22 couples chromosome segregation to polar relaxation. Nature, 524 (7566), 489-+. doi:10.1038/nature14496
Baum D & Baum B (2014). An inside-out origin for the eukaryotic cell. BMC Biol, 12, 76. doi:10.1186/s12915-014-0076-2 Lancaster OM, et al (2013). Mitotic rounding alters cell geometry to ensure efficient bipolar spindle formation. Dev Cell, 25 (3), 270-283. doi:10.1016/j.devcel.2013.03.014
Marinari E, et al (2012). Live-cell delamination counterbalances epithelial growth to limit tissue overcrowding. Nature, 484 (7395), 542-545. doi:10.1038/nature10984
Matthews HK, et al (2012). Changes in ect2 localization couple actomyosin-dependent cell shape changes to mitotic progression. Developmental Cell, 23 (2), 371-383. doi:10.1016/j.devcel.2012.06.003