From: CHU de Québec- Laval University Research Center (Québec, Canada)

Will give a seminar entitled:

Acetyltransferase complexes in epigenetic mechanisms linked to gene regulation and oncogenesis

Our research aim is to understand chromatin dynamics associated with gene regulation and DNA repair. We study protein complexes that control acetylation and methylation of histones, and the composition of chromatin. We dissect the molecular mechanisms of epigenetics, in which signals to chromatin mark different genomic loci and are read by effectors to translate a biological response. Our work has characterized the structure and function of several protein complexes, identifying their intrinsic recognition modules for the epigenetic histone signature. Accurate writing and reading of these epigenetic marks lead to changes in chromatin dynamics, in a targeted manner within the genome, and we study how this process is subverted in specific cancers.

Speaker website