Epigenetic RNA-mediated heredity

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  1. Rassoulzadegan, M, Cuzin, F. Nutrition meets heredity: a case of RNA-mediated transmission of acquired characters. Environ Epigenet. 2018;4 (2):dvy006. doi: 10.1093/eep/dvy006. PubMed PMID:29732170 PubMed Central PMC5920336.
  2. Kohram, F, Fallah, P, Shamsara, M, Bolandi, Z, Rassoulzadegan, M, Soleimani, M et al.. Cell type-dependent functions of microRNA-92a. J. Cell. Biochem. 2018;119 (7):5798-5804. doi: 10.1002/jcb.26765. PubMed PMID:29574928 .
  3. Niavarani, A, Shahrabi Farahani, A, Sharafkhah, M, Rassoulzadegan, M. Pancancer analysis identifies prognostic high-APOBEC1 expression level implicated in cancer in-frame insertions and deletions. Carcinogenesis. 2018;39 (3):327-335. doi: 10.1093/carcin/bgy005. PubMed PMID:29346513 .
  4. Druelle, N, Vieira, A, Shabro, A, Courtney, M, Mondin, M, Rekima, S et al.. Ectopic expression of Pax4 in pancreatic δ cells results in β-like cell neogenesis. J. Cell Biol. 2017;216 (12):4299-4311. doi: 10.1083/jcb.201704044. PubMed PMID:29025873 PubMed Central PMC5716283.
  5. Capovilla, M, Robichon, A, Rassoulzadegan, M. A new paramutation-like example at the Delta gene of Drosophila. PLoS ONE. 2017;12 (3):e0172780. doi: 10.1371/journal.pone.0172780. PubMed PMID:28355214 PubMed Central PMC5371283.
  6. Ghanbarian, H, Wagner, N, Michiels, JF, Cuzin, F, Wagner, KD, Rassoulzadegan, M et al.. Small RNA-directed epigenetic programming of embryonic stem cell cardiac differentiation. Sci Rep. 2017;7 :41799. doi: 10.1038/srep41799. PubMed PMID:28165496 PubMed Central PMC5292948.
  7. Ghanbarian, H, Wagner, N, Polo, B, Baudouy, D, Kiani, J, Michiels, JF et al.. Dnmt2/Trdmt1 as Mediator of RNA Polymerase II Transcriptional Activity in Cardiac Growth. PLoS ONE. 2016;11 (6):e0156953. doi: 10.1371/journal.pone.0156953. PubMed PMID:27270731 PubMed Central PMC4894585.
  8. Grandjean, V, Fourré, S, De Abreu, DA, Derieppe, MA, Remy, JJ, Rassoulzadegan, M et al.. RNA-mediated paternal heredity of diet-induced obesity and metabolic disorders. Sci Rep. 2015;5 :18193. doi: 10.1038/srep18193. PubMed PMID:26658372 PubMed Central PMC4677355.
  9. Rassoulzadegan, M, Cuzin, F. From paramutation to human disease: RNA-mediated heredity. Semin. Cell Dev. Biol. 2015;44 :47-50. doi: 10.1016/j.semcdb.2015.08.007. PubMed PMID:26335266 .
  10. Rassoulzadegan, M, Cuzin, F. Epigenetic heredity: RNA-mediated modes of phenotypic variation. Ann. N. Y. Acad. Sci. 2015;1341 :172-5. doi: 10.1111/nyas.12694. PubMed PMID:25726734 .
  11. Liebers, R, Rassoulzadegan, M, Lyko, F. Epigenetic regulation by heritable RNA. PLoS Genet. 2014;10 (4):e1004296. doi: 10.1371/journal.pgen.1004296. PubMed PMID:24743450 PubMed Central PMC3990477.
  12. Kiani, J, Grandjean, V, Liebers, R, Tuorto, F, Ghanbarian, H, Lyko, F et al.. RNA-mediated epigenetic heredity requires the cytosine methyltransferase Dnmt2. PLoS Genet. 2013;9 (5):e1003498. doi: 10.1371/journal.pgen.1003498. PubMed PMID:23717211 PubMed Central PMC3662642.
  13. Kiani, J, Rassoulzadegan, M. A load of small RNAs in the sperm - how many bits of hereditary information?. Cell Res. 2013;23 (1):18-9. doi: 10.1038/cr.2012.181. PubMed PMID:23266892 PubMed Central PMC3541666.
  14. Kawano, M, Kawaji, H, Grandjean, V, Kiani, J, Rassoulzadegan, M. Novel small noncoding RNAs in mouse spermatozoa, zygotes and early embryos. PLoS ONE. 2012;7 (9):e44542. doi: 10.1371/journal.pone.0044542. PubMed PMID:22984523 PubMed Central PMC3440372.
  15. Ghanbarian, H, Grandjean, V, Cuzin, F, Rassoulzadegan, M. A Network of Regulations by Small Non-Coding RNAs: The P-TEFb Kinase in Development and Pathology. Front Genet. 2011;2 :95. doi: 10.3389/fgene.2011.00095. PubMed PMID:22303389 PubMed Central PMC3268644.
  16. Keber, R, Motaln, H, Wagner, KD, Debeljak, N, Rassoulzadegan, M, Ačimovič, J et al.. Mouse knockout of the cholesterogenic cytochrome P450 lanosterol 14alpha-demethylase (Cyp51) resembles Antley-Bixler syndrome. J. Biol. Chem. 2011;286 (33):29086-97. doi: 10.1074/jbc.M111.253245. PubMed PMID:21705796 PubMed Central PMC3190716.
  17. Cuzin, F, Rassoulzadegan, M. Non-Mendelian epigenetic heredity: gametic RNAs as epigenetic regulators and transgenerational signals. Essays Biochem. 2010;48 (1):101-6. doi: 10.1042/bse0480101. PubMed PMID:20822489 .
  18. Rassoulzadegan, M, Cuzin, F. The making of an organ: RNA mediated developmental controls in mice. Organogenesis. ;6 (1):33-6. . PubMed PMID:20592863 PubMed Central PMC2861741.
  19. Grandjean, V, Gounon, P, Wagner, N, Martin, L, Wagner, KD, Bernex, F et al.. The miR-124-Sox9 paramutation: RNA-mediated epigenetic control of embryonic and adult growth. Development. 2009;136 (21):3647-55. doi: 10.1242/dev.041061. PubMed PMID:19820183 .
  20. Rassoulzadegan, M. A response to 'Mammalian paramutation: a tail's tale?'--a commentary by H. Arnheiter on our paramutation paper. Pigment Cell Melanoma Res. 2009;22 (1):140-1; author reply 142-3. doi: 10.1111/j.1755-148X.2008.00521.x. PubMed PMID:19054343 .
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2016 - La Légion d'Honneur - State (France)

2015 - "Prize ""GenKok""" - Kayseri (Turkey)

2011 - Prix Doyen Lepine - Ville de Nice (France)

2009 - Elected EMBO Member - Europe

1987 - Prix (Biologie Moléculaire) - FRM (France)

1985 - Prix Lacassagne - Cancer (France)

iBV - Institut de Biologie Valrose

"Centre de Biochimie"

Université Nice Sophia Antipolis
Faculté des Sciences
Parc Valrose
06108 Nice cedex 2