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X-WR-CALDESC:Events for iBV
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TZID:Europe/Paris
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TZOFFSETFROM:+0100
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DTSTART:20180325T010000
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DTSTART:20181028T010000
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DTSTART;TZID=Europe/Paris:20181022T113000
DTEND;TZID=Europe/Paris:20181022T113000
DTSTAMP:20260714T235057
CREATED:20181015T073841Z
LAST-MODIFIED:20181015T073938Z
UID:6775-1540207800-1540207800@ibv.unice.fr
SUMMARY:Stéphane OLIET
DESCRIPTION:From Neurocentre Magendie – Inserm U1215 \nwill give a seminar entitled : \nAstroglial regulation of NMDA receptors \n  \nAstroglial cells are considered the housekeepers of the brain since they ensure the clearance of toxic substances that accumulate during neuronal activity and provide neurons with the appropriate energy supply and trophic factors. Beside these well-known functions\, astrocytes also participate actively to synaptic transmission. Astroglial cells respond to synaptic activity through intracellular Ca2+ signaling\, thereby triggering the release of active substances known as gliotransmitters. Such gliotransmitters act in a second to minutes time scale on neighboring neurons to regulate excitabiity. During this seminar\, I would review the work carried out in my group on astroglial D-serine\, an endogenous co-agonist of NMDA receptors (NMDAR). Through the supply of this D-amino acid\, astrocytes regulate NMDAR activity including the most common forms of long-term synaptic plasticity in the brain. Such a regulation highlights the importance of astrocytes for physiological processes like learning and memory but also for neurodegenerative diseases and psychiatric disorders in which NMDAR have been shown to play a key role \nhttps://www.bordeaux-neurocampus.fr/ \n  \n \n 
URL:http://ibv.unice.fr/event/stephane-oliet/
LOCATION:Salle de Conférences\, IPMC\, 660 route des Lucioles\, Valbonne\, 06560\, France
CATEGORIES:Labex SIGNALIFE Seminar
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