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X-WR-CALDESC:Events for iBV
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TZID:Europe/Paris
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TZNAME:CEST
DTSTART:20190331T010000
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DTSTART:20191027T010000
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DTSTART;TZID=Europe/Paris:20191206T103000
DTEND;TZID=Europe/Paris:20191206T103000
DTSTAMP:20260412T211629
CREATED:20190712T102718Z
LAST-MODIFIED:20191129T151441Z
UID:8294-1575628200-1575628200@ibv.unice.fr
SUMMARY:Silvia CAPPELLO
DESCRIPTION:From Max Planck Institute of Psychiatry\, Munich (DEU)\n \nwill give a seminar entitled : \nModeling human neurogenesis with cerebral organoids \n  \n\n\nAbstract  \nMalformations of the human neocortex are present in about 1% of the general population and represent a major cause of developmental disabilities including severe epilepsy. To date\, mouse lines carrying mutations of genes so far identified in human patients with cortical malformations only partially recapitulate the expected cortical phenotypes and therefore do not provide reliable models to entirely understand the molecular and cellular mechanisms responsible for these disorders. \nTherefore we decided to combine the in vivo mouse model and the human-derived cerebral organoids in order to better comprehend the mechanisms involved in the migration of neurons during human brain development and tackle the causes of neurodevelopmental disorders. \nOur results show that we can model human brain development and neuronal migration disorders using human cerebral organoids and contribute to open new avenues to bridge the gap of knowledge between human brain malformations and existing mouse models.
URL:http://ibv.unice.fr/event/silvia-cappello/
LOCATION:Salle de Conférences\, Centre de Biochimie\, 28 avenue Valrose\, Faculté des Sciences\, Parc Valrose\, Nice\, 06100\, France
CATEGORIES:Seminars
ORGANIZER;CN="Mich%C3%A8le%20STUDER":MAILTO:studer@unice.fr
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