BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//iBV - ECPv5.8.1//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:iBV
X-ORIGINAL-URL:http://ibv.unice.fr
X-WR-CALDESC:Events for iBV
BEGIN:VTIMEZONE
TZID:Europe/Paris
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20230326T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20231029T010000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20231030T113000
DTEND;TZID=Europe/Paris:20231030T113000
DTSTAMP:20260404T181145
CREATED:20231013T164009Z
LAST-MODIFIED:20231013T164009Z
UID:12712-1698665400-1698665400@ibv.unice.fr
SUMMARY:Matej KRAJNC
DESCRIPTION:From: Jozef Stefan Institute\, Ljubljana\, SLOVENIA \n  \nWill give a seminar entitled: \n  \nWhat do embryos have in common with retail companies and Google? \n  \nComplex systems are characterized by their mutlidimensionality and intricate interconnections among their components\, which leads to emergent system-scale behavioral patterns that cannot be simply predicted from properties of the individual components. Studying these systems requires systematic quantitative approaches\, including the employment of well-organized and properly structured data models to represent their static states as well as their temporal dynamics. \nThree-dimensional (3D) cellular aggregates can serve as models of tumors and tumor spheroids and can be computationally studied using the vertex model. It is known that vertex models of 3D cell aggregates with a dynamic topology of the cell network\, describing cell reorganizations within the aggregate\, are difficult to implement due to the convoluted architecture of the underlying data model. To solve this\, we propose a reformulation of the vertex model\, called Graph Vertex Model (GVM). GVM stores the topology of the cell network into a knowledge graph\, whose data structure\, defined by a metagraph\, allows capturing the inherent relations between vertices\, edges\, cell interfaces\, and cells. As a result\, cell-rearrangement events in GVM simplify to simple graph transformations that are straight-forward to implement and are unified between 2D and 3D space-filling polygonal and polyhedral packings. \nWe apply a similar approach to live-imaging data of the early fly embryo. To initiate collaborative\, interactive\, and structured buildup of the common knowledge\, we develop GRAPh Embryo project (GRAPE)\, an online queryable graph database that allows interactive analyses of an entire fly embryo with all surface cells accurately segmented\, tracked\, and cell divisions identified. Results of queries in GRAPE are automatically projected color-coded onto a 3D image of the embryo\, additionally represented in a graph format\, and readily downloadable for further analysis. In all\, knowledge graphs are potentially a paradigm-shifting concept that offers countless possibilities to develop suitable data models for structured storage\, analysis\, and manipulation of tissue data. \n  \n \n  \nThe MECABIONIC SEMINARS is part of the action of the new MECABIONIC program at UniCA (https://univ-cotedazur.eu/events/mecabionic). The aim of this seminar series is to highlight recent advances and breakthroughs in mechanobiology and to gather researchers tackling the mechanics of the living. We believe this to be a unique opportunity to foster exciting and insightful discussions among a multi- and inter-disciplinary community of experts focused on the understanding of the fundamental biophysical principles powering life from the molecule to the organism level. \nIn the last decades\, biology has been increasingly becoming a science at the cross-road of mathematics\, physics\, chemistry\, engineering and computer science. Therefore\, it is key to promote synergistic interaction between scientists working in different disciplines that often have difficulties cross-communicating. With the MECABIONIC SEMINAR series\, we intend to break the communication barriers by imposing a pedagogic seminar format adapted to a multi- and inter-disciplinary community of junior and senior scientists. \nThis seminar event will foster interaction among scientists of different UniCA institutions (iBV\, LJAD\, IRCAN\, IPMC\, INPHYNI) and promote new interdisciplinary collaborations. \n  \nSpeaker website
URL:http://ibv.unice.fr/event/matej-krajnc/
LOCATION:Laboratoire J.-A. Dieudonné\, Salle de Conférence\, Parc Valrose\, Nice\, 06100\, France
CATEGORIES:Seminars
ORGANIZER;CN="Matteo%20RAUZI":MAILTO:mrauzi@unice.fr
END:VEVENT
END:VCALENDAR