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DTSTART;TZID=Europe/Paris:20240215T150000
DTEND;TZID=Europe/Paris:20240215T150000
DTSTAMP:20260426T111058
CREATED:20240125T151206Z
LAST-MODIFIED:20240214T165837Z
UID:13214-1708009200-1708009200@ibv.unice.fr
SUMMARY:Julien COLOMBANI
DESCRIPTION:From: University of Copenhagen \nWill give a seminar entitled: \nThe role of two niche-derived signals in coupling \nenvironmental cues with tissue turnover rates and adaptive gut resizing \nRapidly renewable tissues adapt different strategies to cope with environmental insults. While tissue repair is associated with increased intestinal stem cell (ISC) proliferation and accelerated tissue turnover rates\, reduced calorie intake triggers a homeostasis-breaking process causing adaptive resizing of the gut. We uncover a key role of the Drosophila activin\, Dawdle (Daw)\, in coupling nutritional cues with gut plasticity. Daw signals through its receptor\, Baboon\, in progenitor cells to promote their maturation into enterocytes (ECs). Daw is dynamically regulated during starvation-refeeding cycles\, where it couples nutrient intake with progenitor maturation and adaptive resizing of the gut.\nWhile nutrient deprivation reduces tissue turnover\, infection-induced damage of the gut epithelium triggers a regenerative response. The process of regeneration involves intestinal stem cell migration\, proliferation\, and differentiation. While the regulations underpinning SC divisions and differentiation are increasingly well understood\, the signals that guide SCs towards injured areas and ensure their correct positioning within the tissue remains relatively unexplored. We find that PDGF-VEGF-related factor 1 (Pvf1)\, produced by the trachea/vasculature in response to intestinal damage\, acts as a guidance signal to stimulate ISC migration and gut regeneration. \n  \n \n\nSpeaker website
URL:http://ibv.unice.fr/event/julien-colombani/
LOCATION:Salle de Conférences\, Centre de Biochimie\, 28 avenue Valrose\, Faculté des Sciences\, Parc Valrose\, Nice\, 06100\, France
CATEGORIES:Seminars
ORGANIZER;CN="Matteo%20RAUZI":MAILTO:mrauzi@unice.fr
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