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DTSTART:20260329T010000
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DTSTART:20261025T010000
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DTSTART;TZID=Europe/Paris:20260424T110000
DTEND;TZID=Europe/Paris:20260424T110000
DTSTAMP:20260417T013007
CREATED:20251105T183935Z
LAST-MODIFIED:20260310T134334Z
UID:15272-1777028400-1777028400@ibv.unice.fr
SUMMARY:Hugues LORTAT-JACOB
DESCRIPTION:From: Institut de Biologie Structurale\, Grenoble \n  \nWill give a seminar entitled: \nGlycosaminoglycans: Master regulators of molecular encounters at the cell surface \nGAGs are complex polysaccharides\, ubiquitously present at the cell surface and within extracellular matrices (ECM). Through their ability to bind a large array of proteins\, almost 4000 of which have been identified to date – including most signaling proteins – GAGs regulate key biologic processes at the cell–tissue interface. To do so\, GAGs provide scaffolds to ensure that proteins mediating specific functions will be presented at the correct site and time and also impact the stability\, the structure and the reactivity of their protein ligands. \nDuring this seminar I will describe how GAGs and chemokines (a family of chemoattractant cytokines) contribute to maintain haptotactic gradients within tissues along which cells can migrate directionally. Using CXCL12 (stromal cell-derived factor 1) as a model system I will show that GAG-chemokine complex also serves additional purposes that go well beyond a simple immobilization process\, including controlling receptor recognition and activation. \nI will also introduce the notion of specificity in protein-GAG interactions. To understand how protein binding sites can be imprinted along the GAG chain during their biosynthesis I will describe the X-ray crystallographic or CryoEM 3D-structure of several enzymes involved in GAGs polymerization and maturation. \nSpeaker website
URL:http://ibv.unice.fr/event/hugues-lortat-jacob/
LOCATION:Salle de Conférences\, Centre de Biochimie\, 28 avenue Valrose\, Faculté des Sciences\, Parc Valrose\, Nice\, 06100\, France
CATEGORIES:Seminar Series
ORGANIZER;CN="Pascal%20THEROND":MAILTO:therond@unice.fr
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