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DTSTART;TZID=Europe/Paris:20240119T140000
DTEND;TZID=Europe/Paris:20240119T140000
DTSTAMP:20260503T003832
CREATED:20240116T113857Z
LAST-MODIFIED:20240116T114013Z
UID:13168-1705672800-1705672800@ibv.unice.fr
SUMMARY:Emmanuèle HELFER
DESCRIPTION:From: CINAM Marseille \n  \nWill give a seminar entitled: \n  \n\n\n\nCell mechanics upon lamin A/C alterations \n\n\n\n\n\n\nLamin A/C is a crucial component of the nucleus and the impact of lamin A/C alterations has been extensively described at the molecular and nuclear scales\, notably on nucleus mechanical properties. However\, its impact on whole-cell mechanics has been poorly addressed\, even less so in terms of measurable physical parameters. \nIn the present study\, we combined microfluidic experiments with theoretical analyses to provide a quantitative estimation of the whole-cell mechanical properties. This allowed us to characterize the mechanical changes induced in cells by lamin A/C alterations resulting either from Atazanavir treatment\, a protease inhibitor which alters lamin A/C production\, or from lamin A/C R482W mutation associated to type-2 familial partial lipodystrophy (FPLD2). \nWe reveal a distinctive increase in long-time viscosity as a signature of cells affected by lamin A/C alterations. Furthermore\, our results show that the whole-cell response to mechanical stress is driven not only by the nucleus but also by the nucleo-cytoskeleton links and the microtubule network. The enhanced cell viscosity assessed by our microfluidic assay could serve as a valuable diagnosis marker for lamin-related diseases. \n\n\n\n  \nSpeaker website
URL:http://ibv.unice.fr/event/emmanuele-helfer/
LOCATION:Fizeau conference room (5th floor)\, Parc Valrose\, Nice\, France
CATEGORIES:Seminars
ORGANIZER;CN="Matteo%20RAUZI":MAILTO:mrauzi@unice.fr
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