BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//iBV - ECPv5.8.1//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:iBV
X-ORIGINAL-URL:http://ibv.unice.fr
X-WR-CALDESC:Events for iBV
BEGIN:VTIMEZONE
TZID:Europe/Paris
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20220327T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20221030T010000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20220428T090000
DTEND;TZID=Europe/Paris:20220428T090000
DTSTAMP:20260507T170321
CREATED:20220425T163105Z
LAST-MODIFIED:20220425T163105Z
UID:10130-1651136400-1651136400@ibv.unice.fr
SUMMARY:Elke OBER 
DESCRIPTION:From\, NNF Center for Stem Cell Biology\, University of Copenhagen\, Denmark \n  \nWill give a seminar entitled: \nMechanisms of Liver Development and Regeneration \n  \nAbstract: \nThe many essential functions of the liver are mediated by its characteristic tissue architecture. Hepatocytes exhibit a distinct apico-basal polarity\, aligning with their basal side along blood vessels\, while canaliculi form apically and connect hepatocytes to the terminal branches of the biliary network. It is poorly understood how liver progenitors self-organize in vivo to establish the functional 3D tissue organization during development and how it is reestablished following injury. We combine 4D-live cell imaging in zebrafish with genetic\, biophysics and quantitative imaging approaches to capture the cell behaviors and tissue interactions driving these processes at cellular resolution. During development\, we find that differentiating hepatocytes are surprisingly dynamic and undergo a sequence of distinct cellular events essential for the establishment of a functional hepato-biliary ductal network. Our analyses also reveal novel modes of cell-cell communication between different hepatic cell types employing specialized cell protrusions\, including an unexpected instructive function for endothelial cells.
URL:http://ibv.unice.fr/event/elke-ober/
LOCATION:Online
CATEGORIES:Seminars
ORGANIZER;CN="Andreas%20SCHEDL":MAILTO:schedl@unice.fr
END:VEVENT
END:VCALENDAR