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DTSTART:20230326T010000
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DTSTART:20231029T010000
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DTSTART;TZID=Europe/Paris:20231124T120000
DTEND;TZID=Europe/Paris:20231124T120000
DTSTAMP:20260430T013205
CREATED:20230626T083346Z
LAST-MODIFIED:20231124T054247Z
UID:12285-1700827200-1700827200@ibv.unice.fr
SUMMARY:Claire WYART
DESCRIPTION:From: L’Institut du Cerveau et de la Moelle Épinière \n  \nWill give a seminar entitled: \n  \nCerebrospinal fluid-contacting neurons: \nmultimodal cells with diverse roles in the CNS \n  \nThe cerebrospinal fluid (CSF) is a complex solution that circulates around the CNS\, and whose composition changes as a function of an animal’s physiological state. A type of ciliated neurons that are bathed in the CSF — and thus referred to as CSF-contacting neurons (CSF-cNs) are unusual polymodal interoceptive neurons. As chemoreceptors\, CSF-cNs respond to variations in pH and osmolarity and to bacterial metabolites in the CSF. Their activation during infections of the CNS results in secretion of compounds to enhance host survival. As mechanosensory neurons\, CSF-cNs operate together with an extracellular proteinaceous polymer known as the Reissner fibre to detect compression during spinal curvature. Once activated\, CSF-cNs inhibit motor neurons\, premotor excitatory neurons and command neurons to enhance movement speed and stabilize posture. At longer timescales\, CSF-cNs instruct morphogenesis throughout life via the release of neuropeptides that act over long distances on skeletal muscle. Finally\, recent evidence suggests that mouse CSF-cNs may act as neural stem cells in the spinal cord\, inspiring new paths of investigation for repair after injury. \n  \nSpeaker website
URL:http://ibv.unice.fr/event/claire-wyart/
LOCATION:Salle de Conférences\, Centre de Biochimie\, 28 avenue Valrose\, Faculté des Sciences\, Parc Valrose\, Nice\, 06100\, France
CATEGORIES:Seminars
ORGANIZER;CN="Valentina%20CIGLIOLA":MAILTO:Valentina.Cigliola@univ-cotedazur.fr
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