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DTSTART:20240331T010000
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DTSTART;TZID=Europe/Paris:20240322T110000
DTEND;TZID=Europe/Paris:20240322T110000
DTSTAMP:20260430T060510
CREATED:20240129T061638Z
LAST-MODIFIED:20240318T092256Z
UID:13230-1711105200-1711105200@ibv.unice.fr
SUMMARY:Christophe BÉCAVIN
DESCRIPTION:From: IPMC \n  \nWill give a seminar entitled: \n  \nThe Human Lung Cell Atlas \n  \nSince 2015\, we have been contributing to the creation of comprehensive reference maps of human lung cells1\,2. These cellular atlases help us to better understand healthy respiratory pathways and improve the diagnosis\, monitoring\, and treatment of fatal lung diseases3. In this talk\, I will discuss the process of single-cell atlas reconstruction\, beginning with our first large-scale atlas containing 80\,000 cells1. I will then go on to discuss the Human Lung Cell Atlas\, which integrates 2.4 million cells4\, and conclude with our latest atlas\, which includes cells sampled from early-stage COPD (chronic obstructive pulmonary disease) patients. Finally\, from a bioinformatics perspective\, I will address how deep learning models have revolutionized our single-cell atlas reconstruction methods and how foundation models\, such as scGPT5\, are poised to become ubiquitous tools for all atlas-related tasks. \n1 – Deprez\, M. et al. A Single-Cell Atlas of the Human Healthy Airways. Am. J. Respir. Crit. Care Med. 202\, 1636–1645 (2020).\n2 – Ruiz García\, S. et al. Novel dynamics of human mucociliary differentiation revealed by single-cell RNA sequencing of nasal epithelial cultures. Development 146\, dev.177428 (2019).\n3 – Sungnak\, W. et al. SARS-CoV-2 Entry Factors are Highly Expressed in Nasal Epithelial Cells Together with Innate Immune Genes. Nat. Med. 26\, 681–687 (2020).\n4 – Sikkema\, L. et al. An integrated cell atlas of the lung in health and disease. Nat. Med. 29\, 1563–1577 (2023).\n5 – Cui\, H. et al. scGPT: toward building a foundation model for single-cell multi-omics using generative AI. Nat. Methods 1–11 (2024) doi:10.1038/s41592-024-02201-0. \n  \nSpeaker website
URL:http://ibv.unice.fr/event/christophe-becavin/
LOCATION:Salle de Conférences\, Centre de Biochimie\, 28 avenue Valrose\, Faculté des Sciences\, Parc Valrose\, Nice\, 06100\, France
CATEGORIES:Seminars
ORGANIZER;CN="Franck%20DELAUNAY":MAILTO:delaunay@unice.fr
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