Adhesion Signaling and the Tumor Matrix Environment

The extracellular matrix (ECM) and its cellular receptors of the integrin family play a determinant role in tumor development by translating external cues into morphological and behavioural changes.



Our current investigations aim to identify the molecular mechanisms that underlie this process and to elucidate the function of fibronectin splice variants. Spliced forms of fibronectin ( oncofetal FN ) produced by both endothelial cells and certain tumor cells, including invasive glioblastomas, represent a major constituent of the provisional ECM and likely play an important role in capillary morphogenesis, tumor-endothelial cell interactions and recruitment of various host cells to the developing tumor.

In collaboration with the translational and clinical research teams of the Centre A. Lacassagne and the Nice University Hospitals (CHU) we are involved in studies on squamous cell carcinomas of the head and neck (SCCHN). Clearly, aberrant regulation of actin cytoskeleton dynamics contributes to the invasive behavior of these tumors. A major focus of our work addresses the function of cortactin, an actin binding protein encoded by the CTTN/EMS1 gene (frequently amplified in SSCHN and breast tumors).


Last publications

Fibronectin-guided migration of carcinoma collectives. - 2017 - Nature communications - 8 P14105 - Gopal S, Veracini L, Grall D, Butori C, Schaub S, Audebert S, Camoin L, Baudelet E, Radwanska A, Beghelli-de la Forest Divonne S, Violette SM, Weinreb PH, Rekima S, Ilie M, Sudaka A, Hofman P, and Van Obberghen-Schilling,E

A Positive Feed-forward Loop Associating EGR1 and PDGFA Promotes Proliferation and Self-renewal in Glioblastoma Stem Cells. - 2016 - The Journal of biological chemistry - 291 P10684-99 - Sakakini N, Turchi L, Bergon A, Holota H, Rekima S, Lopez F, Paquis P, Almairac F, Fontaine D, Baeza-Kallee N, Van Obberghen-Schilling E, Junier MP, Chneiweiss H, Figarella-Branger D, Burel-Vandenbos F, Imbert J, and Virolle,T

Tenascin-C Orchestrates Glioblastoma Angiogenesis by Modulation of Pro- and Anti-angiogenic Signaling. - 2016 - Cell reports - 17 P2607-2619 - Rupp T, Langlois B, Koczorowska MM, Radwanska A, Sun Z, Hussenet T, Lefebvre O, Murdamoothoo D, Arnold C, Klein A, Biniossek ML, Hyenne V, Naudin E, Velazquez-Quesada I, Schilling O, Van Obberghen-Schilling E, and Orend,G

Elevated Src family kinase activity stabilizes E-cadherin-based junctions and collective movement of head and neck squamous cell carcinomas. - 2015 - Oncotarget - 6 P7570-83 - Veracini L, Grall D, Schaub S, Beghelli-de la Forest Divonne S, Etienne-Grimaldi MC, Milano G, Bozec A, Babin E, Sudaka A, Thariat J, and Van Obberghen-Schilling,E

Integrating genomics in head and neck cancer treatment: Promises and pitfalls. - 2015 - Critical reviews in oncology/hematology - 95 P397-406 - Thariat J, Vignot S, Lapierre A, Falk AT, Guigay J, Van Obberghen-Schilling E, and Milano,G

Fibronectin expression in glioblastomas promotes cell cohesion, collective invasion of basement membrane in vitro and orthotopic tumor growth in mice. - 2014 - Oncogene - 33 P3451-62 - Serres E, Debarbieux F, Stanchi F, Maggiorella L, Grall D, Turchi L, Burel-Vandenbos F, Figarella-Branger D, Virolle T, Rougon G, and Van Obberghen-Schilling,E

Tumorigenic potential of miR-18A* in glioma initiating cells requires NOTCH-1 signaling. - 2013 - Stem cells (Dayton, Ohio) - 31 P1252-65 - Turchi L, Debruyne DN, Almairac F, Virolle V, Fareh M, Neirijnck Y, Burel-Vandenbos F, Paquis P, Junier MP, Van Obberghen-Schilling E, Chneiweiss H, and Virolle,T

Epidermal growth factor receptor protein detection in head and neck cancer patients: a many-faceted picture. - 2012 - Clinical cancer research : an official journal of the American Association for Cancer Research - 18 P1313-22 - Thariat J, Etienne-Grimaldi MC, Grall D, Bensadoun RJ, Cayre A, Penault-Llorca F, Veracini L, Francoual M, Formento JL, Dassonville O, De Raucourt D, Geoffrois L, Giraud P, Racadot S, Morinire S, Milano G, and Van Obberghen-Schilling,E

Contrasted outcomes to gefitinib on tumoral IGF1R expression in head and neck cancer patients receiving postoperative chemoradiation (GORTEC trial 2004-02). - 2012 - Clinical cancer research : an official journal of the American Association for Cancer Research - 18 P5123-33 - Thariat J, Bensadoun RJ, Etienne-Grimaldi MC, Grall D, Penault-Llorca F, Dassonville O, Bertucci F, Cayre A, De Raucourt D, Geoffrois L, Finetti P, Giraud P, Racadot S, Morinire S, Sudaka A, Van Obberghen-Schilling E, and Milano,G

Fibronectin and tenascin-C: accomplices in vascular morphogenesis during development and tumor growth. - 2011 - The International journal of developmental biology - 55 P511-25 - Van Obberghen-Schilling E, Tucker RP, Saupe F, Gasser I, Cseh B, and Orend,G

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Van Obberghen-Schilling Ellen
Group Leader

2001 Prix Inserm Physiologie

1996 Prix jeune chercheur FRM

1991 Prix Hmostase et Thrombose

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Members Team
   Ciais Delphine
Clinical Researchers
   Sudaka Anne
   Ruff Michael
   Efthymiou Georgios
   Grapa Anca
Engineers & Technicians
   Grall Dominique
Photos ...

    January 2018 - E. Van Obberghen Schilling Team
   1 CDD AI - 12 Mois

    November 2017 - E. Van Obberghen Schilling Team
   1 POST-DOC position - 2 years

    October 2013 - E. Van Obberghen Schilling Team
   1 Post-Doc position   Closed

    January 2012 - E. Van Obberghen Schilling Team
   1 POST-DOC position   Closed

    June 2009 - E. Van Obberghen Schilling Team
   1 POST-DOC position   Closed



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