Bio engineering and osteo-articular physiopathology

Our project is focused on bone tissue physiopathology and bone reconstruction in traumatic and tumoral contexts. We aim at developing basic research programs based on major public-health concerns and transfer our results into clinic as quickly as possible.

Bone reconstruction – In vitro 3D bone tissue models

This first axe is dedicated to: (i) the development and transfer (industrial and clinic) of new bone substitutes that will be used for the reconstruction of bone defects; (ii) the engineering of innovative 3D models of bone like constructs, based on the use of bone substitutes associated to bone cells, to study bone tissue microenvironment in vitro.

The performances of the biomaterials we develop are tested in vitro in the presence of bone cells and in vivo in the animal models that we have developed in Nice or in Nantes in collaboration with Olivier Gauthier at the Veterinary School and Jean-Michel Bouler at the Inserm U791 LIOAD. The “BRB” (Blood for Reconstruction of Bone), constituted of calcium phosphate particles and clotted blood, is the first osteoinductive biomaterials that we have patented and that should be transferred to the patient in the course of 2014, thanks to anour industrial partner Graftys. This program strongly involves the surgeons of the team, who run also clinical research projects which aim at developing new mini-invasive surgical methods and computer-assisted surgery.

Concerning 3D culture, we have already developed two different models using bone cells cultured in static conditions. Based on these first systems, our aim is now to develop dynamic conditions using bioreactors, with a focus on models suitable to study the interactions between bone tissue microenvironment and the hematopoietic niche. Lastly, we are investigating new biomaterials that could be used for the treatment of spine defects.


Bone tumours

The second axe is dedicated to: (i) the development of in vivo primary and metastatic bone cancer models; (ii) the design of biomaterials incorporating therapeutic compounds targeting bone tumours.

In vivo cancer models are used to identify therapeutic targets among chemokines and chemokine receptors, which are key partners in the interactions between bone microenvironment and cancer cells. Interestingly, calcium phosphate biomaterials that are used for bone reconstruction can be used as drug delivery systems for the compounds potentially efficient in view of the targets identified in vivo. Accordingly, calcium phosphate biomaterials doped with therapeutic compounds are implanted in vivo to evaluate their potential against bone tumour cells development.

In addition, we will use the 3D models of bone like constructs, based on the use of calcium phosphate biomaterials associated to bone cells, to study bone tissue microenvironment in vitro in the absence or in the presence of cancer cells. Lastly, we will take advantage of these in vitro models for the screening of therapeutic compounds for the treatment of bone pathologies, with a focus on bone tumours and hematopoietic malignancies.


Last publications

Green laser light irradiation enhances differentiation and matrix mineralization of osteogenic cells. - 2016 - Journal of photochemistry and photobiology. B, Biology - 155 P130-6 - Merigo E, Bouvet-Gerbettaz S, Boukhechba F, Rocca JP, Fornaini C, and Rochet,N

Gallium, a promising candidate to disrupt the vicious cycle driving osteolytic metastases. - 2016 - Biochemical pharmacology - Strazic-Geljic I, Guberovic I, Didak B, Schmid-Antomarchi H, Schmid-Alliana A, Boukhechba F, Bouler JM, Scimeca JC, and Verron,E

Design and properties of novel gallium-doped injectable apatitic cements. - 2015 - Acta biomaterialia - 24 P322-32 - Mellier C, Fayon F, Boukhechba F, Verron E, LeFerrec M, Montavon G, Lesoeur J, Schnitzler V, Massiot D, Janvier P, Gauthier O, Bouler JM, and Bujoli,B

Effect of G-CSF on the osteoinductive property of a BCP/blood clot composite. - 2015 - Journal of biomedical materials research. Part A - 103 P2830-8 - Paul AJ, Momier D, Boukhechba F, Michiels JF, Lagadec P, and Rochet,N

Adaptive immune response inhibits ectopic mature bone formation induced by BMSCs/BCP/plasma composite in immune competent mice. - 2014 - Tissue engineering. Part A - Bouvet-Gerbettaz S, Boukhechba F, Balaguer T, Schmid-Antomarchi H, Michiels JF, Scimeca JC, and Rochet,N

Therapeutic strategies for treating osteolytic bone metastases. - 2014 - Drug discovery today - Verron E, Schmid-Antomarchi H, Pascal-Mousselard H, Schmid-Alliana A, Scimeca JC, and Bouler,JM

Postnatal soluble FGFR3 therapy rescues achondroplasia symptoms and restores bone growth in mice. - 2013 - Sci Transl Med - 5 P203ra124 - Garcia S, Dirat B, Tognacci T, Rochet N, Mouska X, Bonnafous S, Patouraux S, Tran A, Gual P, Le Marchand-Brustel Y, Gennero I, and Gouze,E

CXCR7-mediated progression of osteosarcoma in the lungs. - 2013 - Br J Cancer - 109 P1579-85 - Goguet-Surmenian E, Richard-Fiardo P, Guillemot E, Benchetrit M, Gomez-Brouchet A, Buzzo P, Karimdjee-Soilihi B, Alemanno P, Michiels JF, Schmid-Alliana A, and Schmid-Antomarchi,H

CXCR7 receptors facilitate the progression of colon carcinoma within lung not within liver. - 2012 - British journal of cancer - 107 P1944-9 - Guillemot E, Karimdjee-Soilihi B, Pradelli E, Benchetrit M, Goguet-Surmenian E, Millet MA, Larbret F, Michiels JF, Birnbaum D, Alemanno P, Schmid-Antomarchi H, and Schmid-Alliana,A

Gallium as a potential candidate for treatment of osteoporosis. - 2012 - Drug Discov Today - 17 P1127-32 - Verron E, Bouler JM, and Scimeca,JC

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Scimeca Jean-Claude
Group Leader

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Members Team
   Boukhechba Florian
   Lagadec Patricia
   Schmid-Alliana Annie
   Schmid-Antomarchi Heidy
Clinical Researchers
   Amoretti Nicolas
   Boileau Pascal
   Karimdjee Babou
   Odin Guillaume
   Trojani Christophe
   Cohen Charlotte
Engineers & Technicians
   Millet Marie-Ange
   Momier David
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iBV - Institute of Biology Valrose
CNRS UMR7277, Inserm U1091, UNS Université Nice Sophia Antipolis
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