Patrick Collombat
  Team : Collombat Patrick
  activité : Chef d`quipe
  Localisation : Centre de Biochimie
  Tel: +33 492076416
  Fax : +33 492076442

2015 Prix Auguste Loubatires

2014 Prix G. B. Morgagni

2013 A. Bouchardat Award

2013 FG de Sant Award

2013 CG06 Medal

2011 ERC Starting Grant


2009 Avenir INSERM

2009 Schlumberger Prize


Long-Term GABA Administration Induces Alpha Cell-Mediated Beta-like Cell Neogenesis. - 2017 - Cell - 168 P73-85.e11
Ben-Othman N, Vieira A, Courtney M, Record F, Gjernes E, Avolio F, Hadzic B, Druelle N, Napolitano T, Navarro-Sanz S, Silvano S, Al-Hasani K, Pfeifer A, Lacas-Gervais S, Leuckx G, Marroqu L, Thvenet J, Madsen OD, Eizirik DL, Heimberg H, Kerr-Conte J, Pattou F, Mansouri A, and Collombat,P

Artemisinins Target GABAA Receptor Signaling and Impair alpha Cell Identity. - 2017 - Cell - 168 P86-100.e15
Li J, Casteels T, Frogne T, Ingvorsen C, Honor C, Courtney M, Huber KV, Schmitner N, Kimmel RA, Romanov RA, Sturtzel C, Lardeau CH, Klughammer J, Farlik M, Sdelci S, Vieira A, Avolio F, Briand F, Baburin I, Mjek P, Pauler FM, Penz T, Stukalov A, Gridling M, Parapatics K, Barbieux C, Berishvili E, Spittler A, Colinge J, Bennett KL, Hering S, Sulpice T, Bock C, Distel M, Harkany T, Meyer D, Superti-Furga G, Collombat P, Hecksher-Srensen J, and Kubicek,S

GABA triggers pancreatic beta-like cell neogenesis. - 2017 - Cell cycle (Georgetown, Tex.) - 16 P727-728
Vieira A, Ben-Othman N, and Collombat,P

beta-Cell Replacement Strategies: The Increasing Need for a "beta-Cell Dogma". - 2017 - Frontiers in genetics - 8 P75
Vieira A, Druelle N, Avolio F, Napolitano T, Navarro-Sanz S, Silvano S, and Collombat,P

Ectopic expression of Pax4 in pancreatic delta-cells results in beta-like cell neogenesis. - 2017 - The Journal of cell biology
Druelle N, Vieira A, Shabro A, Courtney M, Mondin M, Rekima S, Napolitano T, Silvano S, Navarro-Sanz S, Hadzic B, Avolio F, Rassoulzadegan M, Schmid HA, Mansouri A, and Collombat,P

GABA signaling stimulates alpha-cell-mediated beta-like cell neogenesis. - 2017 - Communicative & integrative biology - 10 Pe1300215
Napolitano T, Avolio F, Vieira A, Ben-Othman N, Courtney M, Gjernes E, Hadzic B, Druelle N, Navarro Sanz S, Silvano S, Mansouri A, and Collombat,P

Pax6 Inactivation in the Adult Pancreas Reveals Ghrelin as Endocrine Cell Maturation Marker. - 2015 - PloS one - 10 Pe0144597
Ahmad Z, Rafeeq M, Collombat P, and Mansouri,A

Pax4 acts as a key player in pancreas development and plasticity. - 2015 - Seminars in cell & developmental biology
Napolitano T, Avolio F, Courtney M, Vieira A, Druelle N, Ben-Othman N, Hadzic B, Navarro S, and Collombat,P

Embryonic stem cell-derived neural progenitors as non-tumorigenic source for dopaminergic neurons. - 2014 - World journal of stem cells - 6 P248-55
Liao MC, Diaconu M, Monecke S, Collombat P, Timaeus C, Kuhlmann T, Paulus W, Trenkwalder C, Dressel R, and Mansouri,A

A genetic mouse model for progressive ablation and regeneration of insulin producing beta-cells. - 2014 - Cell cycle (Georgetown, Tex.) - 13 P3948-57
Shamsi F, Parlato R, Collombat P, and Mansouri,A

From pancreatic islet formation to beta-cell regeneration. - 2013 - Diabetes research and clinical practice
Ben-Othman N, Courtney M, Vieira A, Pfeifer A, Druelle N, Gjernes E, Faurite B, Avolio F, and Collombat,P

Adult duct-lining cells can reprogram into β-like cells able to counter repeated cycles of toxin-induced diabetes. - 2013 - Developmental cell - 26 P86-100
Al-Hasani K, Pfeifer A, Courtney M, Ben-Othman N, Gjernes E, Vieira A, Druelle N, Avolio F, Ravassard P, Leuckx G, Lacas-Gervais S, Ambrosetti D, Benizri E, Hecksher-Sorensen J, Gounon P, Ferrer J, Gradwohl G, Heimberg H, Mansouri A, and Collombat,P

Gastrin: a distinct fate of neurogenin3 positive progenitor cells in the embryonic pancreas. - 2013 - PloS one - 8 Pe70397
Suissa Y, Magenheim J, Stolovich-Rain M, Hija A, Collombat P, Mansouri A, Sussel L, Sosa-Pineda B, McCracken K, Wells JM, Heller RS, Dor Y, and Glaser,B

Reprogramming pancreatic cells to beta cells. - 2013 - Medecine sciences : M/S - 29 P749-55
Vieira A, Druelle N, Courtney M, Avolio F, Ben-Othman N, Pfeifer A, Gjernes E, Faurite B, and Collombat,P

The inactivation of Arx in pancreatic α-cells triggers their neogenesis and conversion into functional β-like cells. - 2013 - PLoS genetics - 9 Pe1003934
Courtney M, Gjernes E, Druelle N, Ravaud C, Vieira A, Ben-Othman N, Pfeifer A, Avolio F, Leuckx G, Lacas-Gervais S, Burel-Vandenbos F, Ambrosetti D, Hecksher-Sorensen J, Ravassard P, Heimberg H, Mansouri A, and Collombat,P

From pancreas morphogenesis to β-cell regeneration. - 2013 - Current topics in developmental biology - 106 P217-38
Avolio F, Pfeifer A, Courtney M, Gjernes E, Ben-Othman N, Vieira A, Druelle N, Faurite B, and Collombat,P

Induction of multiple cycles of pancreatic β-cell replacement. - 2013 - Cell cycle (Georgetown, Tex.) - 12 P3243-4
Pfeifer A, Courtney M, Ben-Othman N, Al-Hasani K, Gjernes E, Vieira A, Druelle N, Avolio F, Faurite B, Mansouri A, and Collombat,P

A regulatory path associated with X-linked intellectual disability and epilepsy links KDM5C to the polyalanine expansions in ARX. - 2013 - American journal of human genetics - 92 P114-25
Poeta L, Fusco F, Drongitis D, Shoubridge C, Manganelli G, Filosa S, Paciolla M, Courtney M, Collombat P, Lioi MB, Gecz J, Ursini MV, and Miano,MG

The homeodomain-containing transcription factors Arx and Pax4 control enteroendocrine subtype specification in mice. - 2012 - PloS one - 7 Pe36449
Beucher A, Gjernes E, Collin C, Courtney M, Meunier A, Collombat P, and Gradwohl,G

Generation of animals allowing the conditional inactivation of the Pax4 gene. - 2012 - Transgenic research - 21 P1215-20
Kordowich S, Serup P, Collombat P, and Mansouri,A

In vivo conversion of adult α-cells into β-like cells: a new research avenue in the context of type 1 diabetes. - 2011 - Diabetes, obesity & metabolism - 13 Suppl 1 P47-52
Courtney M, Pfeifer A, Al-Hasani K, Gjernes E, Vieira A, Ben-Othman N, and Collombat,P

Arx and Nkx2.2 compound deficiency redirects pancreatic alpha- and beta-cell differentiation to a somatostatin/ghrelin co-expressing cell lineage. - 2011 - BMC developmental biology - 11 P52
Kordowich S, Collombat P, Mansouri A, and Serup,P

Reprogramming into pancreatic endocrine cells based on developmental cues. - 2010 - Molecular and cellular endocrinology - 323 P62-9
Kordowich S, Mansouri A, and Collombat,P

Pancreatic beta-cells: from generation to regeneration. - 2010 - Seminars in cell & developmental biology - 21 P838-44
Collombat P, Xu X, Heimberg H, and Mansouri,A

Reprogramming into pancreatic endocrine cells based on developmental cues. - 2010 - Molecular and cellular endocrinology - 315 P11-8
Kordowich S, Mansouri A, and Collombat,P

Alpha cells beget beta cells. - 2009 - Cell - 138 P424-6
Liu Z, and Habener,JF

The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells. - 2009 - Cell - 138 P449-62
Collombat P, Xu X, Ravassard P, Sosa-Pineda B, Dussaud S, Billestrup N, Madsen OD, Serup P, Heimberg H, and Mansouri,A

Arx acts as a regional key selector gene in the ventral telencephalon mainly through its transcriptional repression activity. - 2009 - Developmental biology - 334 P59-71
Colasante G, Sessa A, Crispi S, Calogero R, Mansouri A, Collombat P, and Broccoli,V

Turning on the beta-cell identity in the pancreas. - 2009 - Cell cycle (Georgetown, Tex.) - 8 P3450-1
Collombat P, and Mansouri,A

Pax4 transdifferentiates glucagon-secreting alpha cells to insulin-secreting beta endocrine pancreatic cells. - 2009 - Medecine sciences : M/S - 25 P763-5
Collombat P, and Mansouri,A

Ghrelin is a novel target of Pax4 in endocrine progenitors of the pancreas and duodenum. - 2008 - Developmental dynamics : an official publication of the American Association of Anatomists - 237 P51-61
Wang Q, Elghazi L, Martin S, Martins I, Srinivasan RS, Geng X, Sleeman M, Collombat P, Houghton J, and Sosa-Pineda,B

Arx is a direct target of Dlx2 and thereby contributes to the tangential migration of GABAergic interneurons. - 2008 - The Journal of neuroscience : the official journal of the Society for Neuroscience - 28 P10674-86
Colasante G, Collombat P, Raimondi V, Bonanomi D, Ferrai C, Maira M, Yoshikawa K, Mansouri A, Valtorta F, Rubenstein JL, and Broccoli,V

The homeobox gene Arx is a novel positive regulator of embryonic myogenesis. - 2008 - Cell death and differentiation - 15 P94-104
Biressi S, Messina G, Collombat P, Tagliafico E, Monteverde S, Benedetti L, Cusella De Angelis MG, Mansouri A, Ferrari S, Tajbakhsh S, Broccoli V, and Cossu,G

Inactivation of Arx, the murine ortholog of the X-linked lissencephaly with ambiguous genitalia gene, leads to severe disorganization of the ventral telencephalon with impaired neuronal migration and differentiation. - 2007 - The Journal of neuroscience : the official journal of the Society for Neuroscience - 27 P4786-98
Colombo E, Collombat P, Colasante G, Bianchi M, Long J, Mansouri A, Rubenstein JL, and Broccoli,V

Putting pancreatic cell plasticity to the test. - 2007 - The Journal of clinical investigation - 117 P859-62
Ferrer J, Martìn M, and Servitja,JM

Embryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression. - 2007 - The Journal of clinical investigation - 117 P961-70
Collombat P, Hecksher-Sìrensen J, Krull J, Berger J, Riedel D, Herrera PL, Serup P, and Mansouri,A

Specifying pancreatic endocrine cell fates. - 2006 - Mechanisms of development - 123 P501-12
Collombat P, Hecksher-Sìrensen J, Serup P, and Mansouri,A

Sp8 controls the anteroposterior patterning at the midbrain-hindbrain border. - 2006 - Development (Cambridge, England) - 133 P1779-87
Griesel G, Treichel D, Collombat P, Krull J, Zembrzycki A, van den Akker WM, Gruss P, Simeone A, and Mansouri,A

IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas. - 2006 - The EMBO journal - 25 P1344-52
Mellitzer G, Bonné S, Luco RF, Van De Casteele M, Lenne-Samuel N, Collombat P, Mansouri A, Lee J, Lan M, Pipeleers D, Nielsen FC, Ferrer J, Gradwohl G, and Heimberg,H

In vivo and in vitro tissue-specific expression of green fluorescent protein using the cre-lox system in mouse embryonic stem cells. - 2005 - Stem cells (Dayton, Ohio) - 23 P10-5
Schindehìtte J, Fukumitsu H, Collombat P, Griesel G, Brink C, Baier PC, Capecchi MR, and Mansouri,A

The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the alpha- and beta-cell lineages in the mouse endocrine pancreas. - 2005 - Development (Cambridge, England) - 132 P2969-80
Collombat P, Hecksher-Sìrensen J, Broccoli V, Krull J, Ponte I, Mundiger T, Smith J, Gruss P, Serup P, and Mansouri,A

Genetic determinants of pancreatic epsilon-cell development. - 2005 - Developmental biology - 286 P217-24
Heller RS, Jenny M, Collombat P, Mansouri A, Tomasetto C, Madsen OD, Mellitzer G, Gradwohl G, and Serup,P

Opposing actions of Arx and Pax4 in endocrine pancreas development. - 2003 - Genes & development - 17 P2591-603
Collombat P, Mansouri A, Hecksher-Sorensen J, Serup P, Krull J, Gradwohl G, and Gruss,P

Neurogenin3: a master regulator of pancreatic islet differentiation and regeneration. - Islets - 1 P177-84
Rukstalis JM, and Habener,JF

[Induction of pancreatic ?-like cell regeneration by activation of GABA signaling pathways]. - Medecine sciences : M/S - 33 P565-567
Vieira A, Ben-Othman N, Druelle N, Courtney M, Avolio F, Napolitano T, Gjernes E, Hadzic B, Navarro Sanz S, Silvano S, and Collombat,P



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