Pascal Thérond
  Team : Thérond Pascal
  activité : Chef d`équipe
  Localisation : Centre de Biochimie
  Tel: +33 492076446
  Fax : +33 492076405

2009 Prix Victor Noury Academie des Sciences

2001 Embo YIP



Switch of PKA substrates from Cubitus interruptus to Smoothened in the Hedgehog signalosome complex. - 2014 - Nature communications - 5 P5034
Ranieri N, Thérond PP, and Ruel,L

The mechanisms of Hedgehog signalling and its roles in development and disease. - 2013 - Nature reviews. Molecular cell biology - 14 P416-29
Briscoe J, and Thérond,PP

Distinct Phosphorylations on Kinesin Costal-2 Mediate Differential Hedgehog Signaling Strength. - 2012 - Dev Cell
Ranieri N, Ruel L, Gallet A, Raisin S, and Thérond,PP

Dally and Notum regulate the switch between low and high level Hedgehog pathway signalling. - 2012 - Development (Cambridge, England) - 139 P3168-79
Ayers KL, Mteirek R, Cervantes A, Lavenant-Staccini L, Thérond PP, and Gallet,A

Release and transportation of Hedgehog molecules. - 2012 - Current opinion in cell biology - 24 P173-80

Dynamic phosphorylation of the kinesin Costal-2 in vivo reveals requirement of fused kinase activity for all levels of hedgehog signalling. - 2010 - Dev Biol - 344 P119-28
Raisin S, Ruel L, Ranieri N, Staccini-Lavenant L, and Thérond,PP

The long-range activity of Hedgehog is regulated in the apical extracellular space by the glypican Dally and the hydrolase Notum. - 2010 - Dev Cell - 18 P605-20
Ayers KL, Gallet A, Staccini-Lavenant L, and Thérond,PP

Evaluating Smoothened as a G-protein-coupled receptor for Hedgehog signalling. - 2010 - Trends Cell Biol - 20 P287-98
Ayers KL, and Thérond,PP

Variations in Hedgehog signaling: divergence and perpetuation in Sufu regulation of Gli. - 2009 - Genes Dev - 23 P1843-8
Ruel L, and Thérond,PP

Tow (Target of Wingless), a novel repressor of the Hedgehog pathway in Drosophila. - 2009 - Dev Biol - 329 P280-93
Ayers KL, Rodriguez R, Gallet A, Ruel L, and Thérond,P

Glycosphingolipids control the extracellular gradient of the Drosophila EGFR ligand Gurken. - 2009 - Development - 136 P551-61
Pizette S, Rabouille C, Cohen SM, and Thérond,P

Control of antagonistic components of the hedgehog signaling pathway by microRNAs in Drosophila. - 2008 - Genetics - 179 P429-39
Friggi-Grelin F, Lavenant-Staccini L, and Therond,P

Cellular trafficking of the glypican Dally-like is required for full-strength Hedgehog signaling and wingless transcytosis. - 2008 - Dev Cell - 14 P712-25
Gallet A, Staccini-Lavenant L, and Thérond,PP

The role of kinases in the Hedgehog signalling pathway. - 2008 - EMBO Rep - 9 P330-6
Aikin RA, Ayers KL, and Thérond,PP

Phosphorylation of the atypical kinesin Costal2 by the kinase Fused induces the partial disassembly of the Smoothened-Fused-Costal2-Cubitus interruptus complex in Hedgehog signalling. - 2007 - Development - 134 P3677-89
Ruel L, Gallet A, Raisin S, Truchi A, Staccini-Lavenant L, Cervantes A, and Thérond, PP

Cholesterol modification is necessary for controlled planar long-range activity of Hedgehog in Drosophila epithelia. - 2006 - Development - 133 P407-18
Gallet A, Ruel L, Staccini-Lavenant L, and Thérond, PP

The cis-Golgi Drosophila GMAP has a role in anterograde transport and Golgi organization in vivo, similar to its mammalian ortholog in tissue culture cells. - 2006 - Eur J Cell Biol - 85 P1155-66
Friggi-Grelin F, Rabouille C, and Therond, P

Temporal modulation of the Hedgehog morphogen gradient by a patched-dependent targeting to lysosomal compartment. - 2005 - Dev Biol - 277 P51-62
Gallet A, and Therond, PP

Hedgehog signaling: from the Drosophila cuticle to anti-cancer drugs. - 2005 - Dev Cell - 8 P143-51
Briscoe J, and Thérond, P

Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog. - 2003 - Nat Cell Biol - 5 P907-13
Ruel L, Rodriguez R, Gallet A, Lavenant-Staccini L, and Thérond, PP

Cholesterol modification of hedgehog is required for trafficking and movement, revealing an asymmetric cellular response to hedgehog. - 2003 - Dev Cell - 4 P191-204
Gallet A, Rodriguez R, Ruel L, and Therond, PP

Heart tube patterning in Drosophila requires integration of axial and segmental information provided by the Bithorax Complex genes and hedgehog signaling. - 2002 - Development - 129 P4509-21
Ponzielli R, Astier M, Chartier A, Gallet A, Thérond P, and Sémériva, M

Cubitus interruptus acts to specify naked cuticle in the trunk of Drosophila embryos. - 2002 - Dev Biol - 241 P132-44
Angelats C, Gallet A, Thérond P, Fasano L, and Kerridge, S

Cubitus interruptus-independent transduction of the Hedgehog signal in Drosophila. - 2000 - Development - 127 P5509-22
Gallet A, Angelats C, Kerridge S, and Thérond, PP

Differential requirements of the fused kinase for hedgehog signalling in the Drosophila embryo. - 1999 - Development - 126 P4039-51
Thérond PP, Limbourg Bouchon B, Gallet A, Dussilol F, Pietri T, van den Heuvel M, and Tricoire, H

Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein costal2. - 1997 - Cell - 90 P225-34
Robbins DJ, Nybakken KE, Kobayashi R, Sisson JC, Bishop JM, and Thérond, PP

Phosphorylation of the fused protein kinase in response to signaling from hedgehog. - 1996 - Proc Natl Acad Sci U S A - 93 P4224-8
Thérond PP, Knight JD, Kornberg TB, and Bishop, JM

Functional domains of fused, a serine-threonine kinase required for signaling in Drosophila. - 1996 - Genetics - 142 P1181-98
Thérond P, Alves G, Limbourg-Bouchon B, Tricoire H, Guillemet E, Brissard-Zahraoui J, Lamour-Isnard C, and Busson, D

Segmental polarity in Drosophila melanogaster: genetic dissection of fused in a Suppressor of fused background reveals interaction with costal-2. - 1993 - Genetics - 135 P1047-62
Préat T, Thérond P, Limbourg-Bouchon B, Pham A, Tricoire H, Busson D, and Lamour-Isnard, C

A putative serine/threonine protein kinase encoded by the segment-polarity fused gene of Drosophila. - 1990 - Nature - 347 P87-9
Préat T, Thérond P, Lamour-Isnard C, Limbourg-Bouchon B, Tricoire H, Erk I, Mariol MC, and Busson, D



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