Thierry Lepage
     
  Team : Lepage Thierry
  activité : Chef d`équipe
  Localisation : Sciences Naturelles
  Tel: +33 492076810
  Fax : -
  e-mail: tlepage@unice.fr
     
Awards

2009 Prize Tregouboff in Marine Biology from French Academy of Sciences

2007 Prize "Coup d'Elan pour la recherche" Bettencourt-Foundation 2007

Publications

p38 MAPK as an essential regulator of dorsal-ventral axis specification and skeletogenesis during sea urchin development: a re-evaluation. - 2017 - Development (Cambridge, England) - 144 P2270-2281
Molina MD, Quirin M, Haillot E, Jimenez F, Chessel A, and Lepage,T

A deuterostome origin of the Spemann organiser suggested by Nodal and ADMPs functions in Echinoderms. - 2015 - Nature communications - 6 P8434
Lapraz F, Haillot E, and Lepage,T

The Maternal Maverick/GDF15-like TGF-β Ligand Panda Directs Dorsal-Ventral Axis Formation by Restricting Nodal Expression in the Sea Urchin Embryo. - 2015 - PLoS biology - 13 Pe1002247
Haillot E, Molina MD, Lapraz F, and Lepage,T

Nodal: master and commander of the dorsal-ventral and left-right axes in the sea urchin embryo. - 2013 - Curr Opin Genet Dev - 23 P445-53
Molina MD, de Crozé N, Haillot E, and Lepage,T

Reciprocal signaling between the ectoderm and a mesendodermal left-right organizer directs left-right determination in the sea urchin embryo. - 2012 - PLoS Genet - 8 Pe1003121
Bessodes N, Haillot E, Duboc V, Röttinger E, Lahaye F, and Lepage,T

Maternal Oct1/2 is required for Nodal and Vg1/Univin expression during dorsal-ventral axis specification in the sea urchin embryo. - 2011 - Dev Biol - 357 P440-9
Range R, and Lepage,T

Wnt6 activates endoderm in the sea urchin gene regulatory network. - 2011 - Development (Cambridge, England) - 138 P3297-306
Croce J, Range R, Wu SY, Miranda E, Lhomond G, Peng JC, Lepage T, and McClay,DR

Ancestral regulatory circuits governing ectoderm patterning downstream of Nodal and BMP2/4 revealed by gene regulatory network analysis in an echinoderm. - 2010 - PLoS Genet - 6 Pe1001259
Saudemont A, Haillot E, Mekpoh F, Bessodes N, Quirin M, Lapraz F, Duboc V, Röttinger E, Range R, Oisel A, Besnardeau L, Wincker P, and Lepage,T

Nodal and BMP2/4 pattern the mesoderm and endoderm during development of the sea urchin embryo. - 2010 - Development - 137 P223-35
Duboc V, Lapraz F, Saudemont A, Bessodes N, Mekpoh F, Haillot E, Quirin M, and Lepage,T

Patterning of the dorsal-ventral axis in echinoderms: insights into the evolution of the BMP-chordin signaling network. - 2009 - PLoS Biol - 7 Pe1000248
Lapraz F, Besnardeau L, and Lepage,T

Lefty acts as an essential modulator of Nodal activity during sea urchin oral-aboral axis formation. - 2008 - Dev Biol - 320 P49-59
Duboc V, Lapraz F, Besnardeau L, and Lepage,T

A conserved role for the nodal signaling pathway in the establishment of dorso-ventral and left-right axes in deuterostomes. - 2008 - J Exp Zool B Mol Dev Evol - 310 P41-53
Duboc V, and Lepage,T

FGF signals guide migration of mesenchymal cells, control skeletal morphogenesis [corrected] and regulate gastrulation during sea urchin development. - 2007 - Development - 135 P353-65
Röttinger E, Saudemont A, Duboc V, Besnardeau L, McClay D, and Lepage,T

Cis-regulatory analysis of nodal and maternal control of dorsal-ventral axis formation by Univin, a TGF-beta related to Vg1. - 2007 - Development - 134 P3649-64
Range R, Lapraz F, Quirin M, Marro S, Besnardeau L, and Lepage,T

The genome of the sea urchin Strongylocentrotus purpuratus. - 2006 - Science - 314 P941-52
Sodergren E, Weinstock GM, Davidson EH, Cameron RA, Gibbs RA, Angerer RC, Angerer LM, Arnone MI, Burgess DR, Burke RD, Coffman JA, Dean M, Elphick MR, Ettensohn CA, Foltz KR, Hamdoun A, Hynes RO, Klein WH, Marzluff W, McClay DR, Morris RL, Mushegian A, Rast JP, Smith LC, Thorndyke MC, Vacquier VD, Wessel GM, Wray G, Zhang L, Elsik CG, Ermolaeva O, Hlavina W, Hofmann G, Kitts P, Landrum MJ, Mackey AJ, Maglott D, Panopoulou G, Poustka AJ, Pruitt K, Sapojnikov V, Song X, Souvorov A, Solovyev V, Wei Z, Whittaker CA, Worley K, Durbin KJ, Shen Y, Fedrigo O, Garfield D, Haygood R, Primus A, Satija R, Severson T, Gonzalez-Garay ML, Jackson AR, Milosavljevic A, Tong M, Killian CE, Livingston BT, Wilt FH, Adams N, Bellé R, Carbonneau S, Cheung R, Cormier P, Cosson B, Croce J, Fernandez-Guerra A, Genevi AM, ère M, Goel H, Kelkar J, Morales O, Mulner-Lorillon AJ, Robertson JV, Goldstone B, Cole D, Epel B, Gold ME, Hahn M, Howard-Ashby M, Scally JJ, Stegeman EL, Allgood J, Cool KM, Judkins SS, McCafferty AM, Musante RA, Obar AP, Rawson BJ, Rossetti IR, Gibbons MP, Hoffman A, Leone S, Istrail SC, Materna MP, Samanta V, Stolc W, Tongprasit Q, Tu KF, Bergeron BP, Brandhorst J, Whittle K, Berney DJ, Bottjer C, Calestani K, Peterson E, Chow QA, Yuan E, Elhaik D, Graur JT, Reese I, Bosdet S, Heesun MA, Marra J, Schein MK, Anderson V, Brockton KM, Buckley AH, Cohen SD, Fugmann T, Hibino M, Loza-Coll AJ, Majeske C, Messier SV, Nair Z, Pancer DP, Terwilliger C, Agca E, Arboleda N, Chen AM, Churcher F, Hallböí¶k GW, Humphrey MM, Idris T, Kiyama S, Liang D, Mellott X, Mu G, Murray RP, Olinski F, Raible M, Rowe JS, Taylor K, Tessmar-Raible D, Wang KH, Wilson S, Yaguchi T, Gaasterland BE, Galindo HJ, Gunaratne C, Juliano M, Kinukawa GW, Moy AT, Neill M, Nomura M, Raisch A, Reade MM, Roux JL, Song YH, Su IK, Townley E, Voronina JL, Wong G, Amore M, Branno ER, Brown V, Cavalieri V, Duboc L, Duloquin C, Flytzanis C, Gache F, Lapraz T, Lepage A, Locascio P, Martinez G, Matassi V, Matranga R, Range F, Rizzo E, Röttinger W, Beane C, Bradham C, Byrum T, Glenn S, Hussain G, Manning E, Miranda R, Thomason K, Walton A, Wikramanayke SY, Wu R, Xu CT, Brown L, Chen RF, Gray PY, Lee J, Nam P, Oliveri J, Smith D, Muzny S, Bell J, Chacko A, Cree S, Curry C, Davis H, Dinh S, Dugan-Rocha J, Fowler R, Gill C, Hamilton J, Hernandez S, Hines J, Hume L, Jackson A, Jolivet C, Kovar S, Lee L, Lewis G, Miner M, Morgan LV, Nazareth G, Okwuonu D, Parker LL, Pu R, Thorn R, and Wright,

RTK and TGF-beta signaling pathways genes in the sea urchin genome. - 2006 - Dev Biol - 300 P132-52
Lapraz F, Röttinger E, Duboc V, Range R, Duloquin L, Walton K, Wu SY, Bradham C, Loza MA, Hibino T, Wilson K, Poustka A, McClay D, Angerer L, Gache C, and Lepage,T

Expression pattern of three putative RNA-binding proteins during early development of the sea urchin Paracentrotus lividus. - 2006 - Gene Expr Patterns - 6 P864-72
Röttinger E, Besnardeau L, and Lepage,T

Nemo-like kinase (NLK) acts downstream of Notch/Delta signalling to downregulate TCF during mesoderm induction in the sea urchin embryo. - 2006 - Development - 133 P4341-53
Röttinger E, Croce J, Lhomond G, Besnardeau L, Gache C, and Lepage,T

The sea urchin kinome: a first look. - 2006 - Dev Biol - 300 P180-93
Bradham CA, Foltz KR, Beane WS, Arnone MI, Rizzo F, Coffman JA, Mushegian A, Goel M, Morales J, Geneviere AM, Lapraz F, Robertson AJ, Kelkar H, Loza-Coll M, Townley IK, Raisch M, Roux MM, Lepage T, Gache C, McClay DR, and Manning,G

Zebrafish endoderm formation is regulated by combinatorial Nodal, FGF and BMP signalling. - 2006 - Development - 133 P2189-200
Poulain M, Fürthauer M, Thisse B, Thisse C, and Lepage,T

Left-right asymmetry in the sea urchin embryo is regulated by nodal signaling on the right side. - 2005 - Dev Cell - 9 P147-58
Duboc V, Röttinger E, Lapraz F, Besnardeau L, and Lepage,T

Expression of exogenous mRNAs to study gene function in the sea urchin embryo. - 2004 - Methods Cell Biol - 74 P677-97
Lepage T, and Gache,C

Nodal and BMP2/4 signaling organizes the oral-aboral axis of the sea urchin embryo. - 2004 - Dev Cell - 6 P397-410
Duboc V, Röttinger E, Besnardeau L, and Lepage,T

A Raf/MEK/ERK signaling pathway is required for development of the sea urchin embryo micromere lineage through phosphorylation of the transcription factor Ets. - 2004 - Development - 131 P1075-87
Röttinger E, Besnardeau L, and Lepage,T

Mezzo, a paired-like homeobox protein is an immediate target of Nodal signalling and regulates endoderm specification in zebrafish. - 2002 - Development - 129 P4901-14
Poulain M, and Lepage,T

The pitx2 homeobox protein is required early for endoderm formation and nodal signaling. . - 2001 - Dev Biol - 229 P287-306
Faucourt M, Houliston E, Besnardeau L, Kimelman D, and Lepage,T

nacre encodes a zebrafish microphthalmia-related protein that regulates neural-crest-derived pigment cell fate. - 1999 - Development - 126 P3757-67
Lister JA, Robertson CP, Lepage T, Johnson SL, and Raible,DW

GSK3beta/shaggy mediates patterning along the animal-vegetal axis of the sea urchin embryo. - 1998 - Development - 125 P2489-98
Emily-Fenouil F, Ghiglione C, Lhomond G, Lepage T, and Gache,C

Structure of the gene encoding the sea urchin blastula protease 10 (BP10), a member of the astacin family of Zn2+-metalloproteases. - 1996 - Eur J Biochem - 238 P744-51
Lhomond G, Ghiglione C, Lepage T, and Gache,C

Signal transduction by cAMP-dependent protein kinase A in Drosophila limb patterning. - 1995 - Nature - 373 P711-5
Lepage T, Cohen SM, Diaz-Benjumea FJ, and Parkhurst,SM

Structure of the sea urchin hatching enzyme gene. - 1994 - Eur J Biochem - 219 P845-54
Ghiglione C, Lhomond G, Lepage T, and Gache,C

Cell-autonomous expression and position-dependent repression by Li+ of two zygotic genes during sea urchin early development. - 1993 - EMBO J - 12 P87-96
Ghiglione C, Lhomond G, Lepage T, and Gache,C

Spatial expression of the hatching enzyme gene in the sea urchin embryo. - 1992 - Dev Biol - 150 P23-32
Lepage T, Sardet C, and Gache,C

Spatial and temporal expression pattern during sea urchin embryogenesis of a gene coding for a protease homologous to the human protein BMP-1 and to the product of the Drosophila dorsal-ventral patterning gene tolloid. - 1992 - Development - 114 P147-63
Lepage T, Ghiglione C, and Gache,C

Early expression of a collagenase-like hatching enzyme gene in the sea urchin embryo. - 1990 - EMBO J - 9 P3003-12
Lepage T, and Gache,C

Purification and characterization of the sea urchin embryo hatching enzyme. - 1989 - J Biol Chem - 264 P4787-93
Lepage T, and Gache,C

 

 

 
  Contact US :
      - Webmasters
      - Director
 
iBV - Institute of Biology Valrose
CNRS UMR7277, Inserm U1091, UNS Université Nice Sophia Antipolis
Parc Valrose
06108 Nice cedex 2 France
 
 
Institute :
  - Presentation
  - Flow Chart
  - Financial Partners
  - Imaging Facility
  - Flow Cytometry
  - Molecular Biology
  - Histopathology
  - Job Offers
  - Access
 
       
 
 
Research teams:
- Amri Ez-Zoubir
- Arkowitz Robert
- Besse Florence
- Braendle Christian
- Chaboissier Marie-Christine
- Collombat Patrick
- Dani Christian
- Delaunay Franck
- Fürthauer Maximilian
- Gouze Elvire
- Hubstenberger Arnaud
- Hueber Anne-Odile
- Lamonerie Thomas
- Léopold Pierre
- Lepage Thierry
- Morpheme Team
- Noselli Stéphane
- Rassoulzadegan Minoo
- Rauzi Matteo
- Sandoz Guillaume
- Schedl Andreas
- Scimeca Jean-Claude
- Soriani Olivier
- Studer Michele
- Thérond Pascal
- Van Obberghen-Schilling Ellen
- Virolle Thierry
- Wagner Kay Dietrich
 
News & events :
  - Publications
  - News
  - Job Offers
Agenda :
  - Seminars
  - HDR
  - Thesis
  - Full List
  - Congresses
Contacts :
  - Institute
  - Research teams
  - Common facilities
  - General phonebook