Stem cells and differentiation

Adipoblasts, osteoblasts, chondroblasts and skeletal myoblasts are derived from a common mesenchymal precursor with a close and a reciprocal relationship between these programs of differentiation. Ectopic formation of fat cells could originate in the defective regulation of the stem cell differentiation process. Research in our laboratory is focused on in vitro and in vivo differentiation of mouse embryonic stem cells and of stem cells isolated from human adult adipose tissue. Our on-going projects are to identify regulatory genes and to study signaling pathways involved in mesenchymal differentiation of stem cells.



Last publications

Differentiation of human induced pluripotent stem cells into brown and white adipocytes: Role of Pax3. - 2013 - Stem Cells - Mohsen-Kanson T, Hafner AL, Wdziekonski B, Takashima Y, Villageois P, Carri A, ère M, Svensson C, Bagnis B, Chignon-Sicard PA, Svensson L, Casteilla A, Smith C, and Dani,

Targeting cancer stem cells expressing an embryonic signature with anti-proteases to decrease their tumor potential. - 2013 - Cell Death Dis - 4 Pe706 - Darini CY, Martin P, Azoulay S, Drici MD, Hofman P, Obba S, Dani C, and Ladoux,A

Developmental Origins of the Adipocyte Lineage: New Insights from Genetics and Genomics Studies. - 2011 - Stem Cell Rev - Billon N, and Dani,C

Small RNA sequencing reveals miR-642a-3p as a novel adipocyte-specific microRNA and miR-30 as a key regulator of human adipogenesis. - 2011 - Genome Biol - 12 PR64 - Zaragosi LE, Wdziekonski B, Brigand KL, Villageois P, Mari B, Waldmann R, Dani C, and Barbry,P

Isolation of a highly myogenic CD34-negative subset of human skeletal muscle cells free of adipogenic potential. - 2010 - Stem Cells - 28 P753-64 - Pisani DF, Dechesne CA, Sacconi S, Delplace S, Belmonte N, Cochet O, Clement N, Wdziekonski B, Villageois AP, Butori C, Bagnis C, Di Santo JP, Kurzenne JY, Desnuelle C, and Dani,C

Activin a plays a critical role in proliferation and differentiation of human adipose progenitors. - 2010 - Diabetes - 59 P2513-21 - Zaragosi LE, Wdziekonski B, Villageois P, Keophiphath M, Maumus M, Tchkonia T, Bourlier V, Mohsen-Kanson T, Ladoux A, Elabd C, Scheideler M, Trajanoski Z, Takashima Y, Amri EZ, Lacasa D, Sengenes C, Ailhaud G, Clément K, Bouloumie A, Kirkland JL, and Dani,C

Activation of hedgehog signaling inhibits osteoblast differentiation of human mesenchymal stem cells. - 2009 - Stem Cells - 27 P703-13 - Plaisant M, Fontaine C, Cousin W, Rochet N, Dani C, and Peraldi,P

Hedgehog Signaling Alters Adipocyte Maturation of Human Mesenchymal Stem Cells. - 2008 - Stem Cells - Fontaine Cousin Plaisant Dani Peraldi ,C W M C P

Autocrine fibroblast growth factor 2 signaling is critical for self-renewal of human multipotent adipose-derived stem cells. - 2006 - Stem Cells - 24 P2412-9 - Zaragosi Ailhaud Dani ,LE G C

Transplantation of a multipotent cell population from human adipose tissue induces dystrophin expression in the immunocompetent mdx mouse. - 2005 - J Exp Med - 201 P1397-405 - Rodriguez Pisani Dechesne Turc-Carel Kurzenne Wdziekonski Villageois Bagnis Breittmayer Groux Ailhaud Dani ,AM D CA C JY B A C JP H G C

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Dani Christian
Group Leader

1989 Prix jeune chercheur FRM

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iBV - Institute of Biology Valrose
CNRS UMR7277, Inserm U1091, UNS Université Nice Sophia Antipolis
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06108 Nice cedex 2 France
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