Cellular and molecular regulation of fat mass

The increase in the frequency of overweight/obese people has reached a qualified epidemic stage with more than one billion overweight (IMC > 25 kg/m2) and at least 300 millions clinically obese (BMI > 30 kg/m2) with tremendous costs for health care systems. A positive energy balance, which is accompanied by an increase in body weight due to increase in the white adipose tissue mass, is resulting from an imbalance between energy intake and energy expenditure.

There are two types of adipose tissue, white adipose tissue (WAT) and brown adipose tissue (BAT). WAT plays a central role in the control of energy homeostasis. In contrast to WAT BAT is specialized in adaptive thermogenesis in which the uncoupling protein1 plays a key role. In contrast to early contention, healthy adult humans possess BAT with a potential for metabolic significance. Active BAT was found in small amounts in healthy adult human localized in various anatomical sites.

In mice and humans, islands of brown adipocytes emerge within WAT depots after prolonged exposure to a PPARγ ligand, a nuclear receptor of the PPAR family (Peroxisome Proliferator-Activated Receptors). These functional adipocytes, termed “brite” (brown-in-white) adipocytes, are embryologically different from genuine brown adipocytes but are functional. Therefore, the identification of factors leading to increased mass/activity of human BAT are of great interest for the treatment of overweight and obesity as well as for associated diseases.

We set up a unique cellular model (mesenchymal stem cells), i.e. multipotent stem cells derived from human adipose tissue (hMADS cells), which differentiate into white adipocytes and are also able to convert into functional brown (brite) adipocytes upon chronic activation of PPARγ. Our current investigations aim to identify the cellular and molecular mechanisms that underlie the conversion of white to brown adipocytes and to analyze key metabolic pathways and mitochondriogenesis in white versus brown adipocytes.


 

 

Last publications

Pleiotropic physiological roles of PPARs and fatty acids: A tribute to Paul Grimaldi. - 2017 - Biochimie - 136 P1-2 - Abumrad NA, Amri EZ, Luquet S, and Forest,C

Control of adipogenesis by oxylipins, GPCRs and PPARs. - 2017 - Biochimie - 136 P3-11 - Barquissau V, Ghandour RA, Ailhaud G, Klingenspor M, Langin D, Amri EZ, and Pisani,DF

Age-Dependent Control of Energy Homeostasis by Brown Adipose Tissue in Progeny Subjected to Maternal Diet-Induced Fetal Programming. - 2017 - Diabetes - 66 P627-639 - Dumortier O, Roger E, Pisani DF, Casamento V, Gautier N, Lebrun P, Johnston H, Lopez P, Amri EZ, Jousse C, Fafournoux P, Prentki M, Hinault C, and Van Obberghen,E

Pharmacological modulation of LMNA SRSF1-dependent splicing abrogates diet-induced obesity in mice. - 2017 - International journal of obesity (2005) - 41 P390-401 - Santo J, Lopez-Herrera C, Apolit C, Bareche Y, Lapasset L, Chavey C, Capozi S, Mahuteau-Betzer F, Najman R, Fornarelli P, Lopez-Mejía IC, Béranger G, Casas F, Amri EZ, Pau B, Scherrer D, and Tazi,J

The K+ channel TASK1 modulates β-adrenergic response in brown adipose tissue through the mineralocorticoid receptor pathway. - 2016 - FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 30 P909-22 - Pisani DF, Beranger GE, Corinus A, Giroud M, Ghandour RA, Altirriba J, Chambard JC, Mazure NM, Bendahhou S, Duranton C, Michiels JF, Frontini A, Rohner-Jeanrenaud F, Cinti S, Christian M, Barhanin J, and Amri,EZ

IP-receptor and PPARs trigger the conversion of human white to brite adipocyte induced by carbaprostacyclin. - 2016 - Biochimica et biophysica acta - 1864 P285-93 - Ghandour RA, Giroud M, Vegiopoulos A, Herzig S, Ailhaud G, Amri EZ, and Pisani,DF

Control of bone and fat mass by oxytocin. - 2016 - Hormone molecular biology and clinical investigation - 28 P95-104 - Amri EZ, and Pisani,DF

miR-125b affects mitochondrial biogenesis and impairs brite adipocyte formation and function. - 2016 - Molecular metabolism - 5 P615-25 - Giroud M, Pisani DF, Karbiener M, Barquissau V, Ghandour RA, Tews D, Fischer-Posovszky P, Chambard JC, Knippschild U, Niemi T, Taittonen M, Nuutila P, Wabitsch M, Herzig S, Virtanen KA, Langin D, Scheideler M, and Amri,EZ

Let-7i-5p represses brite adipocyte function in mice and humans. - 2016 - Scientific reports - 6 P28613 - Giroud M, Karbiener M, Pisani DF, Ghandour RA, Beranger GE, Niemi T, Taittonen M, Nuutila P, Virtanen KA, Langin D, Scheideler M, and Amri,EZ

White-to-brite conversion in human adipocytes promotes metabolic reprogramming towards fatty acid anabolic and catabolic pathways. - 2016 - Molecular metabolism - 5 P352-65 - Barquissau V, Beuzelin D, Pisani DF, Beranger GE, Mairal A, Montagner A, Roussel B, Tavernier G, Marques MA, Moro C, Guillou H, Amri EZ, and Langin,D

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Amri Ez-Zoubir
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Members Team
Researchers
   Ailhaud Gérard
   Chambard Jean-Claude
   Pisani Didier
   Rochet Nathalie
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   Balaguer Thierry
   Roux Christian
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   Colson Cécilia
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    September 2016 - Z. Amri Team
   1 PhD position 3 years   Closed

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