The differential spatiotemporal expression pattern of shelterin genes throughout lifespan
Wagner KD, Ying Y, Leong W, Jiang J, Hu X, Chen Y,
Michiels JF, Lu Y, Gilson E, Wagner N, Ye J. in Aging
(Albany NY). 2017 Apr,9(4):1219-1232. doi:
The differential spatiotemporal expression pattern of shelterin genes throughout lifespan.
Shelterin forms the core complex of telomere proteins and plays critical roles in protecting
telomeres against unwanted activation of the DNA damage response and in Emaintaining telomere length
homeostasis. Although shelterin expression is believed to be ubiquitous for stabilization of
chromosomal ends. Evidences suggest that some shelterin subunits have tissue-specific functions.
However, very little is known regarding how shelterin subunit gene expression is regulated during
development and aging. Using two different animal models, the mouse and zebrafish, we reveal herein
that shelterin subunits exhibit distinct spatial and temporal expression patterns that do not
correlate with the proliferative status of the organ systems examined. Together, this work shows
that the shelterin subunits exhibit distinct spatiotemporal expression patterns, suggesting
important tissue-specific functions during development and aging.